Evidence map›Paper›PMID 26245721›Full record

ArticleClinical rheumatology2016

The influence of age at disease onset on disease activity and disability: results from the Ontario Best Practices Research Initiative.

T N Ruban, B Jacob, J E Pope, E C Keystone, C Bombardier, B Kuriya

Abstract read
PubMed Publisher
In one paragraph

Article in Clinical rheumatology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Clinical and Sonographic Pattern of Late-Onset and Early-Onset Rheumatoid Arthritis: Comparative Study.Clinical medicine insights. Arthritis and musculoskeletal disorders · 2026
    Article
  5. Article
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Observational
  19. Article
  20. Prevalence of and factors associated with dysfunctional low back pain in patients with rheumatoid arthritis.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

T N RubanRheumatology Division, University of Toronto, Sunnybrook Hospital, 2075 Bayview Avenue, Suite M1-400, Toronto, ON, M4N 3M5, Canada. thanu.ruban1@gmail.com.
B JacobUniversity of Toronto, 200 Elizabeth Street, 13EN-22, Toronto, ON, M5G 2C4, Canada.
J E PopeDivision of Rheumatology, Department of Medicine, Western University, St. Joseph's Health Care, 268 Grosvenor Street, London, ON, N6A 4V2, Canada.
E C KeystoneThe Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, Room 2-006 Box 4, 60 Murray Street, Toronto, ON, M5T 3L9, Canada.
C BombardierUniversity of Toronto, Canada, Suite 2-008 Box 7, 60 Murray Street, Toronto, ON, M5T 3L9, Canada.
B KuriyaThe Rebecca MacDonald Centre for Arthritis and Autoimmune Disease, Mount Sinai Hospital, University of Toronto, 2nd Floor, Room 2-008, 60 Murray Street, Toronto, ON, M5T 3L9, Canada.
University of Toronto · CAMount Sinai Hospital · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aims to compare characteristics between late-onset rheumatoid arthritis (RA) and young-onset RA and determine the association between age at disease onset and disease severity. We cross-sectionally studied 971 patients at the time of entry into the Ontario Best Practices Research Initiative, a registry of RA patients followed up in routine care. We restricted patients to ≤5 years of disease duration. Late-onset RA was defined as an onset ≥60 years of age and young-onset RA <60 years. Group differences were compared, and multivariate linear regression models were used to test the influence of age at onset on Disease Activity Score in 28 Joints with erythrocyte sedimentation rate (DAS28-ESR), Clinical Disease Activity Index (CDAI), and Health Assessment Questionnaire (HAQ) scores. The swollen joint count (6.2 vs. 5.3), acute phase reactants (C-reactive protein (CRP) 17.4 vs. 11.8 mg/L, ESR 30.6 vs. 21.5 mm/h), and comorbidity burden were higher in late-onset RA compared to young-onset RA (p < 0.01). Mean DAS28-ESR (4.6 vs. 4.3) and HAQ (1.2 vs. 1.1) scores were higher in late-onset RA patients (p < 0.05). Late-onset RA patients received more initial disease-modifying antirheumatic drug (DMARD) monotherapy and corticosteroids in comparison to greater DMARD/biologic combination therapy in young-onset RA patients (p < 0.05). Adjusted multivariate analyses showed that late-onset RA was independently associated with higher mean DAS28-ESR and HAQ scores, but not CDAI. Late-onset RA patients have greater disease activity that may contribute to disability early in the disease course. Despite this, initial treatment consists of less combination DMARD and biologic use in late-onset RA patients. This may have implications for future response to therapy and development of joint damage, disability, and comorbidities in this group.

Indexed as

Persons with DisabilitiesAdultAgedAge FactorsAge of OnsetAntirheumatic AgentsArthritis, RheumatoidDisability EvaluationDisease ProgressionFemaleHumansMaleMiddle AgedOntarioRegistriesSeverity of Illness IndexAntirheumatic AgentsAge of disease onsetDisease activityElderly onsetRheumatoid arthritis

Identifiers

PMID26245721
OpenAlexW1070505374

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.