Trial reportScientific reports2015
The Bounds Of Education In The Human Brain Connectome.
Trial report in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Cognitive Assessment Tools for Screening Older Adults With Low Levels of Education: A Critical Review.Frontiers in psychiatry · 2019Pooled it
- A Systematic Review for Functional Neuroimaging Studies of Cognitive Reserve Across the Cognitive Aging Spectrum.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2018Pooled it
- Error unawareness as a driver of cognitive decline in individuals at risk for Alzheimer's disease.Communications biology · 2026Article
- Protective role of parenthood on age-related brain function in mid- to late-life.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Resting-state functional connectivity is modulated by cognitive reserve in early Parkinson's disease.Frontiers in psychology · 2023Article
- Inner Hemispheric and Interhemispheric Connectivity Balance in the Human Brain.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- APOE ε4 and cognitive reserve effects on the functional network in the Alzheimer's disease spectrum.Brain imaging and behavior · 2021Article
- Diet, Exercise, Lifestyle, and Mental Distress among Young and Mature Men and Women: A Repeated Cross-Sectional Study.Nutrients · 2020Article
- Electroconvulsive therapy modulates functional interactions between submodules of the emotion regulation network in major depressive disorder.Translational psychiatry · 2020Article
- Functional connectome biotypes of chemotherapy-related cognitive impairment.Journal of cancer survivorship : research and practice · 2020Article
- Multivariate neuroanatomical correlates of behavioral and psychological symptoms in dementia and the moderating role of education.NeuroImage. Clinical · 2020Article
- Functional Connectivity of Successful Picture-Naming: Age-Specific Organization and the Effect of Engaging in Stimulating Activities.Frontiers in aging neuroscience · 2020Article
- APOE Variant (rs405509) might Modulate the Effect of Sex and Educational Level on Cognitive Impairment Risk in a Taiwanese Population.International journal of environmental research and public health · 2019Article
- The Influence of Genetic Factors and Cognitive Reserve on Structural and Functional Resting-State Brain Networks in Aging and Alzheimer's Disease.Frontiers in aging neuroscience · 2019Review
- Cognitive Profiles and Functional Connectivity in First-Episode Schizophrenia Spectrum Disorders - Linking Behavioral and Neuronal Data.Frontiers in psychology · 2019Article
- The left frontal cortex supports reserve in aging by enhancing functional network efficiency.Alzheimer's research & therapy · 2018Article
- Cognitive Reserve Relates to Functional Network Efficiency in Alzheimer's Disease.Frontiers in aging neuroscience · 2018Article
- The independent influences of age and education on functional brain networks and cognition in healthy older adults.Human brain mapping · 2017Article
- Disrupted topological organization of structural networks revealed by probabilistic diffusion tractography in Tourette syndrome children.Human brain mapping · 2017Article
- Brain functional connectivity difference in the complete network of an entire village: the role of social network size and embeddedness.Scientific reports · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inter-individual heterogeneity is evident in aging; education level is known to contribute for this heterogeneity. Using a cross-sectional study design and network inference applied to resting-state fMRI data, we show that aging was associated with decreased functional connectivity in a large cortical network. On the other hand, education level, as measured by years of formal education, produced an opposite effect on the long-term. These results demonstrate the increased brain efficiency in individuals with higher education level that may mitigate the impact of age on brain functional connectivity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.