ArticleBMC plant biology2015
Genome-wide identification of Calcineurin B-Like (CBL) gene family of plants reveals novel conserved motifs and evolutionary aspects in calcium signaling events.
Article in BMC plant biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed, 94 citations in OpenAlex.
- Calcium-Dependent Protein Kinases in Plants: Structure, Signaling, and Multifaceted Regulatory Roles in Development and Stress Adaptation.International journal of molecular sciences · 2026Review
- An evolutionary conserved CBL1-CIPK6 complex of oil persimmon involved in responses to ABA, salt and drought stress.BMC plant biology · 2025Article
- Genome-Wide Association Studies for Grain Micronutrient Concentration in Spring Wheat (Plants (Basel, Switzerland) · 2025Article
- Decoding the CBL gene family in durum wheat: Insights into dual ABA signaling pathways and calcium-mediated drought tolerance.The plant genome · 2025Article
- Understanding the salt overly sensitive pathway in Prunus: Identification and characterization of NHX, CIPK, and CBL genes.The plant genome · 2024Article
- Engineered Nanomaterial Coatings for Food Packaging: Design, Manufacturing, Regulatory, and Sustainability Implications.Micromachines · 2024Review
- The Roles of Calcineurin B-like Proteins in Plants under Salt Stress.International journal of molecular sciences · 2023Review
- Genome-Wide Identification of the CDPK Gene Family and Their Involvement in Taproot Cracking in Radish.International journal of molecular sciences · 2023Article
- Comparison of Transcriptome between Tolerant and Susceptible Rice Cultivar Reveals Positive and Negative Regulators of Response toInternational journal of molecular sciences · 2023Article
- The putative myristoylome of Physcomitrium patens reveals conserved features of myristoylation in basal land plants.Plant cell reports · 2023Article
- Genome-wide analysis of the CML gene family and its response to melatonin in common bean (Phaseolus vulgaris L.).Scientific reports · 2023Article
- Calcium signalling in weeds under herbicide stress: An outlook.Frontiers in plant science · 2023Article
- The calcium connection: exploring the intricacies of calcium signaling in plant-microbe interactions.Frontiers in plant science · 2023Review
- The captivating role of calcium in plant-microbe interaction.Frontiers in plant science · 2023Review
- Insight into the CBL and CIPK gene families in pecan (Carya illinoinensis): identification, evolution and expression patterns in drought response.BMC plant biology · 2022Article
- Article
- The safety of nanomaterials in food production and packaging.Current research in food science · 2022Review
- Calcium Mediated Cold Acclimation in Plants: Underlying Signaling and Molecular Mechanisms.Frontiers in plant science · 2022Review
- Delineating Calcium Signaling Machinery in Plants: Tapping the Potential through Functional Genomics.Current genomics · 2021Review
- Genome-Wide Analysis of the Apple CBL Family Reveals That Mdcbl10.1 Functions Positively in Modulating Apple Salt Tolerance.International journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCalcium ions, the most versatile secondary messenger found in plants, are involved in the regulation of diverse arrays of plant growth and development, as well as biotic and abiotic stress responses. The calcineurin B-like proteins are one of the most important genes that act as calcium sensors.
resultsIn this study, we identified calcineurin B-like gene family members from 38 different plant species and assigned a unique nomenclature to each of them. Sequence analysis showed that, the CBL proteins contain three calcium binding EF-hand domain that contains several conserved Asp and Glu amino acid residues. The third EF-hand of the CBL protein was found to posses the D/E-x-D calcium binding sensor motif. Phylogenetic analysis showed that, the CBL genes fall into six different groups. Additionally, except group B CBLs, all the CBL proteins were found to contain N-terminal palmitoylation and myristoylation sites. An evolutionary study showed that, CBL genes are evolved from a common ancestor and subsequently diverged during the course of evolution of land plants. Tajima's neutrality test showed that, CBL genes are highly polymorphic and evolved via decreasing population size due to balanced selection. Differential expression analysis with cold and heat stress treatment led to differential modulation of OsCBL genes.
conclusionsThe basic architecture of plant CBL genes is conserved throughout the plant kingdom. Evolutionary analysis showed that, these genes are evolved from a common ancestor of lower eukaryotic plant lineage and led to broadening of the calcium signaling events in higher eukaryotic organisms.
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