Evidence map›Paper›PMID 26245322›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2015

Rheumatoid Factor Is Associated With the Distribution of Hand Joint Destruction in Rheumatoid Arthritis.

Chikashi Terao, Noriyuki Yamakawa, Koichiro Yano, Iris M Markusse, Katsunori Ikari, Shinji Yoshida, Moritoshi Furu, Motomu Hashimoto, Hiromu Ito, Takao Fujii and 12 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 7 institutions in 4 countries.

Chikashi TeraoKyoto University Graduate School of Medicine, Kyoto, Japan, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, and Broad Institute, Cambridge, Massachusetts.
Noriyuki YamakawaKyoto University Graduate School of Medicine, Kyoto, Japan.
Koichiro YanoTokyo Women's Medical University, Tokyo, Japan.
Iris M MarkusseLeiden University Medical Center, Leiden, The Netherlands.
Katsunori IkariTokyo Women's Medical University and CREST Program, Japan Science and Technology Agency, Tokyo, Japan.
Shinji YoshidaTokyo Women's Medical University, Tokyo, Japan.
Moritoshi FuruKyoto University Graduate School of Medicine, Kyoto, Japan.
Motomu HashimotoKyoto University Graduate School of Medicine, Kyoto, Japan.
Hiromu ItoKyoto University Graduate School of Medicine, Kyoto, Japan.
Takao FujiiKyoto University Graduate School of Medicine, Kyoto, Japan.
Koichiro OhmuraKyoto University Graduate School of Medicine, Kyoto, Japan.
Kosaku MurakamiKyoto University Graduate School of Medicine, Kyoto, Japan.
Meiko TakahashiKyoto University Graduate School of Medicine, Kyoto, Japan.
Masahide HamaguchiKyoto Prefectural University of Medicine, Graduate School of Medical Science, Kyoto, Japan.
Yasuharu TabaraKyoto University Graduate School of Medicine, Kyoto, Japan.
Atsuo TaniguchiTokyo Women's Medical University, Tokyo, Japan.
Shigeki MomoharaTokyo Women's Medical University, Tokyo, Japan.
Soumya RaychaudhuriBrigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, Broad Institute, Cambridge, Massachusetts, and University of Manchester and Manchester Academic Health Sciences Centre, Manchester, UK.
Cornelia F AllaartLeiden University Medical Center, Leiden, The Netherlands.
Hisashi YamanakaTokyo Women's Medical University, Tokyo, Japan.
Tsuneyo MimoriKyoto University Graduate School of Medicine, Kyoto, Japan.
Fumihiko MatsudaKyoto University Graduate School of Medicine, Kyoto, Japan.
Kyoto University · JPTokyo Women's Medical University · JPLeiden University Medical Center · NLBrigham and Women's Hospital · USJapan Science and Technology Agency · JPKyoto Prefectural University of Medicine · JPManchester Academic Health Science Centre · GB

Funding

Discovery and Functional Impact of Common and Rare Variants in RAR01AR063759 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI Soumya Raychaudhuri · 2013 to 2026
$5.4M
Fine-mapping the MHC associations in rheumatoid arthritis from GWAS dataR01AR062886 · NIAMS · BRIGHAM AND WOMEN'S HOSPITAL · PI RAYCHAUDHURI, SOUMYA · 2012 to 2013
$783k
NIAMS NIH HHS R01 AR062886NIAMS NIH HHS R01 AR063759
6 · The paper itself

Abstract

objectiveRheumatoid arthritis (RA) is a chronic disease leading to joint destruction. Although many studies have addressed factors potentially correlated with the speed of joint destruction, less attention has been paid to the distribution of joint destruction in patients with RA. In this study, destruction of the hand bones in patients with RA was classified into 2 anatomic subgroups, the fingers and the non-fingers, with the aim of analyzing which factors are associated with destruction of the finger joints.

methodsA total of 1,215 Japanese patients with RA were recruited from 2 different populations. The degree of joint destruction was assessed using the total modified Sharp/van der Heijde score (SHS) of radiographic joint damage. The SHS score of joint damage in the finger joints was used as the dependent variable, and the SHS score in the non-finger joints was used as a covariate. Age, sex, disease duration, smoking, C-reactive protein level, treatment for RA, and positivity for and levels of anti-citrullinated protein antibodies and rheumatoid factor (RF) were evaluated as candidate correlates. Overall effect sizes were assessed in a meta-analysis. In addition, associations observed in the Japanese patients were compared to those in a cohort of 157 Dutch RA patients in the BeSt study (a randomized, controlled trial involving 4 different strictly specified treatment strategies for early RA).

resultsNot surprisingly, disease duration in Japanese patients with RA was associated with the finger SHS score (P ≤ 0.00037). Both positivity for and levels of RF showed significant associations with the finger SHS score after adjustment for covariates (P = 0.0022 and P = 8.1 × 10(-7) , respectively). These associations were also true in relation to the time-averaged finger SHS score. An association between RF positivity and the finger SHS score was also observed in Dutch patients with RA in the BeSt study (P = 0.049).

conclusionPositivity for and levels of RF are associated with finger joint destruction independent of non-finger joint destruction and other covariates. Our findings suggest that there are different mechanisms of joint destruction operating in the finger joints of patients with RA.

Indexed as

AdultAgedAntirheumatic AgentsArthritis, RheumatoidAsian PeopleAutoantibodiesCohort StudiesDisease ProgressionFemaleFinger JointFoot JointsHand JointsHLA-DRB1 ChainsHumansJapanLinear ModelsAntirheumatic AgentsAutoantibodiescyclic citrullinated peptideHLA-DRB1 ChainsMethotrexatePeptides, CyclicRheumatoid Factor

Identifiers

PMID26245322
PMCPMC6676493
OpenAlexW1565437929

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.