ArticleJournal of neurophysiology2015
Modeling and simulating the neuromuscular mechanisms regulating ankle and knee joint stiffness during human locomotion.
Article in Journal of neurophysiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04778852 (Quantitative Assessment of Training Effects Using a Wearable Exoskeleton in Parkinson Disease Patients), which is not on this map. Cited by 37 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Quantitative Assessment of Training Effects Using a Wearable Exoskeleton in Parkinson Disease Patients
Who cites it
37 citing papers in PubMed.
- Why inverse simulations overestimate optimal ankle exoskeleton assistance: the role of bi-articular coordination and joint stiffness.Journal of neuroengineering and rehabilitation · 2026Article
- Evidence-informed methodological approaches for coupled neuromusculoskeletal-finite element analysis workflows in orthopaedic biomechanics.Frontiers in bioengineering and biotechnology · 2026Article
- Advancements in Understanding Spasticity: A Neuromusculoskeletal Modeling Perspective.Journal of clinical medicine · 2025Review
- Myoelectric Control in Rehabilitative and Assistive Soft Exoskeletons: A Comprehensive Review of Trends, Challenges, and Integration with Soft Robotic Devices.Biomimetics (Basel, Switzerland) · 2025Review
- Article
- Assessing low-back loading during lifting using personalized electromyography-driven trunk models and NIOSH-based risk levels.Frontiers in bioengineering and biotechnology · 2025Article
- Article
- Insights into muscle metabolic energetics: Modelling muscle-tendon mechanics and metabolic rates during walking across speeds.PLoS computational biology · 2024Article
- Tele-Impedance control of a virtual avatar based on EMG and M-IMU sensors: a proof-of-concept.Scientific reports · 2024Article
- Variable-stiffness prosthesis improves biomechanics of walking across speeds compared to a passive device.Scientific reports · 2024Article
- An assessment of co-contraction in reinnervated muscle.Regenerative medicine · 2024Article
- The Simultaneous Model-Based Estimation of Joint, Muscle, and Tendon Stiffness is Highly Sensitive to the Tendon Force-Strain Relationship.IEEE transactions on bio-medical engineering · 2024Article
- Higher coactivations of lower limb muscles increase stability during walking on slippery ground in forward dynamics musculoskeletal simulation.Scientific reports · 2023Article
- Non-linear properties of the Achilles tendon determine ankle impedance over a broad range of activations in humans.The Journal of experimental biology · 2023Article
- Assisting walking balance using a bio-inspired exoskeleton controller.Journal of neuroengineering and rehabilitation · 2023Article
- EMG-Based Estimation of Lower Limb Joint Angles and Moments Using Long Short-Term Memory Network.Sensors (Basel, Switzerland) · 2023Article
- The impact of age-related increase in passive muscle stiffness on simulated upper limb reaching.Royal Society open science · 2023Article
- Virtual Stiffness: A Novel Biomechanical Approach to Estimate Limb Stiffness of a Multi-Muscle and Multi-Joint System.Sensors (Basel, Switzerland) · 2023Article
- Deep-Learning to Map a Benchmark Dataset of Non-amputee Ambulation for Controlling an Open Source Bionic Leg.IEEE robotics and automation letters · 2022Article
- Reduced Achilles Tendon Stiffness Disrupts Calf Muscle Neuromechanics in Elderly Gait.Gerontology · 2022Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This work presents an electrophysiologically and dynamically consistent musculoskeletal model to predict stiffness in the human ankle and knee joints as derived from the joints constituent biological tissues (i.e., the spanning musculotendon units). The modeling method we propose uses electromyography (EMG) recordings from 13 muscle groups to drive forward dynamic simulations of the human leg in five healthy subjects during overground walking and running. The EMG-driven musculoskeletal model estimates musculotendon and resulting joint stiffness that is consistent with experimental EMG data as well as with the experimental joint moments. This provides a framework that allows for the first time observing 1) the elastic interplay between the knee and ankle joints, 2) the individual muscle contribution to joint stiffness, and 3) the underlying co-contraction strategies. It provides a theoretical description of how stiffness modulates as a function of muscle activation, fiber contraction, and interacting tendon dynamics. Furthermore, it describes how this differs from currently available stiffness definitions, including quasi-stiffness and short-range stiffness. This work offers a theoretical and computational basis for describing and investigating the neuromuscular mechanisms underlying human locomotion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.