Evidence map›Paper›PMID 26245274›Full record

ArticleClinical oral investigations2016

Relationship between periodontal parameters and plasma cytokine profiles in pregnant woman with preterm birth or low birth weight.

Francisco Mesa, Elena Pozo, Francisco O'Valle, Alberto Puertas, Antonio Magan-Fernandez, Eva Rosel, Manuel Bravo

Erratum issuedOpen access · greenAbstract read
PubMed Publisher
In one paragraph

Article in Clinical oral investigations, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 6 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 2 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 2 syntheses or guidelines pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Article
  5. Review
  6. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Francisco MesaPeriodontology Department, School of Dentistry, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain. fmesa@ugr.es.
Elena PozoPeriodontology Department, School of Dentistry, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain.
Francisco O'VallePathology Department, School of Medicine, University of Granada, Avda. De Madrid s/n, 18012, Granada, Spain.
Alberto PuertasDepartment of Obstetrics and Gynecology, Virgen de las Nieves University Hospital, Avda. Fuerzas Armadas 2, 18014, Granada, Spain.
Antonio Magan-FernandezPeriodontology Department, School of Dentistry, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain.
Eva RoselDepartment of Preventive Dentistry and Epidemiology, School of Dentistry, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain.
Manuel BravoDepartment of Preventive Dentistry and Epidemiology, School of Dentistry, University of Granada, Campus de Cartuja s/n, 18071, Granada, Spain.
Universidad de Granada · ESHospital Universitario Virgen de las Nieves · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe aim was to determine whether clinical periodontal parameters are associated with plasma anti- and/or pro-inflammatory cytokines in pregnant woman with preterm birth (PB) or low birth weight (LBW) neonates. MATERIALS AND

methodsAn observational case-control study was performed in 131 puerperal women: mothers of PB/LBW neonates (cases, n = 67) and mothers of full-term normal-weight neonates (controls, n = 64). Sociodemographic and periodontal data was gathered from all participants, and interleukin (IL)-1β, IL-6, IL-8, IL-10, IL-17, IL-23, and tumor necrosis factor alpha (TNF-α) were determined in plasma.

resultsIn multiple linear regression models, clinical attachment loss was associated with TNF-α (0.28 ± 0.14; 95% confidence interval (CI) [0.006, 0.553]) and IL-1β (0.43 ± 0.21; 95%CI [0.018, 0.842]), independent of group membership. IL-1β (-1.67 ± 0.27, 95%CI [-2.199, -1.141]), IL-6 (-0.86 ± 0.27; 95%CI [-1.389, -0.331]), and IL-8 (-3.84 ± 0.50, 95%CI [-4.820, -2.860]) were lower, and IL-10 (0.86 ± 0.26; 95%CI [0.350, 1.370]) was higher in cases versus controls after adjusting for potential confounders.

conclusionsClinical attachment loss was associated with plasma TNF-α and IL-1β levels. No plasma cytokine profiles suggestive of systemic inflammatory response were observed in the pregnant women with PB/LBW neonates. CLINICAL RELEVANCE: Clinical attachment loss, as the main periodontal measure, is associated with TNF-α and IL-1β plasma levels in pregnant women. No relationship was found between PB/LBW and the markers of systemic inflammatory response assessed in this study.

Indexed as

Infant, Low Birth WeightPeriodontal IndexPremature BirthCase-Control StudiesCytokinesFemaleHumansInfant, NewbornInflammationInterleukin-10PregnancyTumor Necrosis Factor-alphaCytokinesInterleukin-10Tumor Necrosis Factor-alphaChronic periodontitisCytokinesEnzyme-linked immunosorbent assayPremature birth

Identifiers

PMID26245274
OpenAlexW2156854664

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.