ArticleScientific reports2015
Estrogen deficiency heterogeneously affects tissue specific stem cells in mice.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Morin Attenuates Hyperglycemia and Metabolic Dysregulation in Ovariectomized Diabetic Mouse Model.Medical sciences (Basel, Switzerland) · 2026Article
- Estrogen Deprivation and Periodontitis Interact Across Multiple Tissues.bioRxiv : the preprint server for biology · 2026Article
- Paracrine effect of human stem cell-derived progenitor cells on remodeling of the vagina.NPJ Regenerative medicine · 2025Article
- Rice Bran Supplementation Ameliorates Gut Dysbiosis and Muscle Atrophy in Ovariectomized Mice Fed with a High-Fat Diet.Nutrients · 2023Article
- Sex Hormones and Satellite Cell Regulation in Women.Translational sports medicine · 2022Review
- Natural estrogens enhance the engraftment of human hematopoietic stem and progenitor cells in immunodeficient mice.Haematologica · 2021Article
- Secretomes of human pluripotent stem cell-derived smooth muscle cell progenitors upregulate extracellular matrix metabolism in the lower urinary tract and vagina.Stem cell research & therapy · 2021Article
- Human Umbilical Cord Mesenchymal Stem Cell-induced Osterix, Bone Morphogenetic Protein-2, and Tartrate-resistant Acid Phosphatase Expression in Osteoporotic Mandibular Bone.European journal of dentistry · 2021Article
- Article
- Follicle-stimulating hormone impairs dental pulp stem cells odontogenic differentiation.Journal of cellular and molecular medicine · 2020Article
- Water Extract ofFoods (Basel, Switzerland) · 2020Article
- Influence of estradiol treatment on bone marrow cell differentiation in collagenase-induced arthritis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2020Article
- Estrogen Deficiency Potentiates Thioacetamide-Induced Hepatic Fibrosis in Sprague-Dawley Rats.International journal of molecular sciences · 2019Article
- Estrogen Regulates the Satellite Cell Compartment in Females.Cell reports · 2019Article
- Impaired redox regulation of estrogen metabolizing proteins is important determinant of human breast cancers.Cancer cell international · 2019Review
- Intramembranous ossification and endochondral ossification are impaired differently between glucocorticoid-induced osteoporosis and estrogen deficiency-induced osteoporosis.Scientific reports · 2018Article
- Fusions of Tumor-derived Endothelial Cells with Dendritic Cells Induces Antitumor Immunity.Scientific reports · 2017Article
- Efficacy and Safety of Immuno-Magnetically Sorted Smooth Muscle Progenitor Cells Derived from Human-Induced Pluripotent Stem Cells for Restoring Urethral Sphincter Function.Stem cells translational medicine · 2017Article
- Smooth Muscle Progenitor Cells Derived From Human Pluripotent Stem Cells Induce Histologic Changes in Injured Urethral Sphincter.Stem cells translational medicine · 2016Article
- Mesenchymal progenitors in osteopenias of diverse pathologies: differential characteristics in the common shift from osteoblastogenesis to adipogenesis.Scientific reports · 2016Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Postmenopausal disorders are frequently observed in various organs, but their relationship with estrogen deficiency and mechanisms remain unclear. As tissue-specific stem cells have been found to express estrogen receptors, we examined the hypothesis that estrogen deficiency impairs stem cells, which consequently contributes to postmenopausal disorders. Six-week-old C57BL/6 female mice were ovariectomized, following which they received 17β-estradiol replacement or vehicle (control). Sham-operated mice were used as healthy controls. All mice were killed for evaluation 2 months after treatments. Compared with the healthy control, ovariectomy significantly decreased uterine weight, which was partially recovered by 17β-estradiol replacement. Ovariectomy significantly increased the numbers of c-kit-positive hematopoietic stem/progenitor cells in bone marrow, but impaired their capacity to grow mixed cell-type colonies in vitro. Estrogen replacement further increased the numbers of c-kit-positive hematopoietic stem/progenitor cells in bone marrow, without significantly affecting colony growth in vitro. The number of CD105-positive mesenchymal stem cells in bone marrow also significantly decreased after ovariectomy, but completely recovered following estrogen replacement. Otherwise, neither ovariectomy nor estrogen replacement changed the number of Pax7-positive satellite cells, which are a skeletal muscle-type stem cell. Estrogen deficiency heterogeneously affected tissue-specific stem cells, suggesting a likely and direct relationship with postmenopausal disorders.
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