ArticleeLife2015
Low-noise encoding of active touch by layer 4 in the somatosensory cortex.
Article in eLife, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed.
- An elastic segment of the whisker shaft enables coding of the whisking phase via whisker torsion in rats and mice.Anatomical record (Hoboken, N.J. : 2007) · 2026Article
- Encoding performance of cortical neurons critically depends on their morphological and neurophysiological properties.PLoS biology · 2026Article
- Microglia Modulate Information Processing in the Mouse Barrel Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Increased excitability of layer 5 neocortical pyramidal neurons and its contribution to seizure activity in Gabrg2 gene-deficient mice.iScience · 2026Article
- Sensory adaptation in the barrel cortex during active sensation in the behaving mouse.Scientific reports · 2024Article
- Sub-threshold neuronal activity and the dynamical regime of cerebral cortex.Nature communications · 2024Article
- Synaptotagmin 7 Sculpts Short-Term Plasticity at a High Probability Synapse.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Reproducible and fully automated testing of nocifensive behavior in mice.Cell reports methods · 2023Article
- Integrated information theory (IIT) 4.0: Formulating the properties of phenomenal existence in physical terms.PLoS computational biology · 2023Article
- Dynamics of cortical contrast adaptation predict perception of signals in noise.Nature communications · 2023Article
- Large-scale neural recordings call for new insights to link brain and behavior.Nature neuroscience · 2022Review
- Continuous, multidimensional coding of 3D complex tactile stimuli by primary sensory neurons of the vibrissal system.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Of mice and monkeys: Somatosensory processing in two prominent animal models.Progress in neurobiology · 2021Review
- Behavioral and Neural Bases of Tactile Shape Discrimination Learning in Head-Fixed Mice.Neuron · 2020Article
- Independent representations of self-motion and object location in barrel cortex output.PLoS biology · 2020Article
- Article
- Distinct synchronization, cortical coupling and behavioral function of two basal forebrain cholinergic neuron types.Nature neuroscience · 2020Article
- A system for tracking whisker kinematics and whisker shape in three dimensions.PLoS computational biology · 2020Article
- Projection-specific Activity of Layer 2/3 Neurons Imaged in Mouse Primary Somatosensory Barrel Cortex During a Whisker Detection Task.Function (Oxford, England) · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
Cortical spike trains often appear noisy, with the timing and number of spikes varying across repetitions of stimuli. Spiking variability can arise from internal (behavioral state, unreliable neurons, or chaotic dynamics in neural circuits) and external (uncontrolled behavior or sensory stimuli) sources. The amount of irreducible internal noise in spike trains, an important constraint on models of cortical networks, has been difficult to estimate, since behavior and brain state must be precisely controlled or tracked. We recorded from excitatory barrel cortex neurons in layer 4 during active behavior, where mice control tactile input through learned whisker movements. Touch was the dominant sensorimotor feature, with >70% spikes occurring in millisecond timescale epochs after touch onset. The variance of touch responses was smaller than expected from Poisson processes, often reaching the theoretical minimum. Layer 4 spike trains thus reflect the millisecond-timescale structure of tactile input with little noise.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.