Evidence map›Paper›PMID 26244931›Full record

ArticleCell metabolism2015

Browning of Subcutaneous White Adipose Tissue in Humans after Severe Adrenergic Stress.

Labros S Sidossis, Craig Porter, Manish K Saraf, Elisabet Børsheim, Ravi S Radhakrishnan, Tony Chao, Arham Ali, Maria Chondronikola, Ronald Mlcak, Celeste C Finnerty and 3 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 225 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
225citing papers in PubMed, 1 pooled it
27.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

225 citing papers in PubMed, 1 synthesis or guideline pooled it, 384 citations in OpenAlex.

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  18. Advances in Adipose Tissue Biology.Endocrine reviews · 2026
    Review
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165 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 2 countries.

Labros S SidossisMetabolism Unit, Shriners Hospitals for Children - Galveston, 815 Market Street, Galveston, TX 77550, USA; Department of Nutrition and Dietetics, Harokopio University, El. Venizelou 70, Kallithea 176 76, Greece; Department of Internal Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Institute of Translational Sciences, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA. Electronic address: lasidoss@utmb.edu.
Craig PorterMetabolism Unit, Shriners Hospitals for Children - Galveston, 815 Market Street, Galveston, TX 77550, USA; Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
Manish K SarafMetabolism Unit, Shriners Hospitals for Children - Galveston, 815 Market Street, Galveston, TX 77550, USA; Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
Elisabet BørsheimMetabolism Unit, Shriners Hospitals for Children - Galveston, 815 Market Street, Galveston, TX 77550, USA; Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
Ravi S RadhakrishnanDepartment of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
Tony ChaoMetabolism Unit, Shriners Hospitals for Children - Galveston, 815 Market Street, Galveston, TX 77550, USA; Department of Preventive Medicine and Community Healthy, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
Arham AliDepartment of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
Maria ChondronikolaMetabolism Unit, Shriners Hospitals for Children - Galveston, 815 Market Street, Galveston, TX 77550, USA; Department of Preventive Medicine and Community Healthy, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
Ronald MlcakDepartment of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
Celeste C FinnertyInstitute of Translational Sciences, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA; Sealy Center for Molecular Medicine, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
Hal K HawkinsDepartment of Pathology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
Tracy Toliver-KinskyDepartment of Anesthesiology, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
David N HerndonMetabolism Unit, Shriners Hospitals for Children - Galveston, 815 Market Street, Galveston, TX 77550, USA; Department of Surgery, University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA.
Shriners Hospitals for Children - Galveston · USThe University of Texas Medical Branch at Galveston · US

Funding

UTMB Clinical and Translational Science AwardUL1TR001439 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI URBAN, RANDALL J · 2015 to 2024
$40.0M
Project 9: The role of androgen/corticosteroid in fat, muscle and glucose metabolism of burn victimsP50GM060338 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI HERNDON, DAVID N. · 2000 to 2017
$24.2M
UTMB Clinical and Translational Science AwardUL1TR000071 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI BRASIER, ALLAN R. · 2012 to 2014
$14.4M
MODULATION OF THE POSTBURN HYPERMETABOLIC RESPONSER01GM056687 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI HERNDON, DAVID N. · 1998 to 2017
$9.0M
UTMB Clinical and Translational Science AwardKL2TR001441 · NCATS · UNIVERSITY OF TEXAS MED BR GALVESTON · PI AMEREDES, BILL T · 2015 to 2024
$4.0M
POSTDOCTORAL TRAINING IN TRAUMA &BURNST32GM008256 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI Celeste Campbell Finnerty, Oscar E. Suman-Vejas · 1990 to 2026
$4.0M
NCATS NIH HHS KL2 TR001441NCATS NIH HHS UL1 TR000071NCATS NIH HHS UL1TR000071NCATS NIH HHS UL1 TR001439NIGMS NIH HHS P50 GM060338NIGMS NIH HHS P50-GM60338NIGMS NIH HHS R01-GM05668NIGMS NIH HHS R01 GM056687NIGMS NIH HHS T32 GM008256
6 · The paper itself

Abstract

Since the presence of brown adipose tissue (BAT) was confirmed in adult humans, BAT has become a therapeutic target for obesity and insulin resistance. We examined whether human subcutaneous white adipose tissue (sWAT) can adopt a BAT-like phenotype using a clinical model of prolonged and severe adrenergic stress. sWAT samples were collected from severely burned and healthy individuals. A subset of burn victims were prospectively followed during their acute hospitalization. Browning of sWAT was determined by the presence of multilocular adipocytes, uncoupling protein 1 (UCP1), and increased mitochondrial density and respiratory capacity. Multilocular UCP1-positive adipocytes were found in sWAT samples from burn patients. UCP1 mRNA, mitochondrial density, and leak respiratory capacity in sWAT increased after burn trauma. Our data demonstrate that human sWAT can transform from an energy-storing to an energy-dissipating tissue, which opens new research avenues in our quest to prevent and treat obesity and its metabolic complications.

Indexed as

Stress, PhysiologicalAdipose Tissue, BrownAdipose Tissue, WhiteAdolescentBurnsChildChild, PreschoolEnergy MetabolismFemaleHumansIon ChannelsMaleMitochondriaMitochondrial ProteinsUncoupling Protein 1Ion ChannelsMitochondrial ProteinsUCP1 protein, humanUncoupling Protein 1

Identifiers

PMID26244931
PMCPMC4541608
OpenAlexW1923854859

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.