ArticleBiophysical journal2015
Cell-Size Homeostasis and the Incremental Rule in a Bacterial Pathogen.
Article in Biophysical journal, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers.
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Who cites it
55 citing papers in PubMed, 123 citations in OpenAlex.
- Control of cell division by anbioRxiv : the preprint server for biology · 2026Article
- Stochasticity in mammalian cell growth rates drives cell-to-cell variability independently of cell size and divisions.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Inferring bacterial cell size dynamics across media conditions.Scientific reports · 2026Article
- Nonlinear memory in cell-division dynamics across species.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Coupling Bacterial Cell Size Regulation with Clonal Proliferation Dynamics Reveals Cell Division Based on Surface Area.bioRxiv : the preprint server for biology · 2025Article
- A generalized adder for cell size homeostasis: Effects on stochastic clonal proliferation.Biophysical journal · 2025Article
- Evolutionary Advantage of Cell Size Control.Physical review letters · 2025Article
- Bacterial cell size modulation along the growth curve across nutrient conditions.bioRxiv : the preprint server for biology · 2024Article
- A GeneralizedbioRxiv : the preprint server for biology · 2024Article
- Differential growth regulates asymmetric size partitioning inLife science alliance · 2024Article
- Scaling of stochastic growth and division dynamics: A comparative study of individual rod-shaped cells in the Mother Machine and SChemostat platforms.Molecular biology of the cell · 2024Article
- The sizes of life.PloS one · 2023Article
- Cellular resource allocation strategies for cell size and shape control in bacteria.The FEBS journal · 2022Review
- Effects of antibiotics on bacterial cell morphology and their physiological origins.Biochemical Society transactions · 2022Review
- Coupling of growth rate and developmental tempo reduces body size heterogeneity in C. elegans.Nature communications · 2022Article
- Article
- Nutrient and salt depletion synergistically boosts glucose metabolism in individual Escherichia coli cells.Communications biology · 2022Article
- Article
- Article
- The Ethanologenic Bacterium Zymomonas mobilis Divides Asymmetrically and Exhibits Heterogeneity in DNA Content.Applied and environmental microbiology · 2021Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
How populations of growing cells achieve cell-size homeostasis remains a major question in cell biology. Recent studies in rod-shaped bacteria support the "incremental rule" where each cell adds a constant length before dividing. Although this rule explains narrow cell-size distributions, its mechanism is still unknown. We show that the opportunistic pathogen Pseudomonas aeruginosa obeys the incremental rule to achieve cell-length homeostasis during exponential growth but shortens its cells when entering the stationary phase. We identify a mutant, called frik, which has increased antibiotic sensitivity, cells that are on average longer, and a fraction of filamentous cells longer than 10 μm. When growth slows due to entry in stationary phase, the distribution of frik cell sizes decreases and approaches wild-type length distribution. The rare filamentous cells have abnormally large nucleoids, suggesting that a deficiency in DNA segregation prevents cell division without slowing the exponential elongation rate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.