Trial reportScientific reports2015
Arteriovenous Blood Metabolomics: A Readout of Intra-Tissue Metabostasis.
Trial report in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed.
- Divergent skeletal muscle metabolite exchange in insulin-like growth factor-1-stimulated myotubes and resistance-exercised human muscle.Experimental physiology · 2026Article
- Decoding cancer across scales with metabolomics.Nature reviews. Cancer · 2026Review
- Metabolic and regulatory adaptations of Staphylococcus epidermidis to host stresses.FEMS microbiology reviews · 2026Review
- Article
- The plasma metabolome of juvenile idiopathic arthritis varies according to subtype and underlying inflammatory status.Pediatric rheumatology online journal · 2024Article
- Differences in Brain Metabolite Profiles Between Normothermia and Hypothermia.Journal of Korean medical science · 2024Article
- Metabolomics: An Emerging "Omics" Platform for Systems Biology and Its Implications for Huntington Disease Research.Metabolites · 2023Review
- Impact of acute stress on murine metabolomics and metabolic flux.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Review
- Association between aberrant amino acid metabolism and nonchromosomal modifications fetal structural anomalies: A cohort study.Frontiers in endocrinology · 2023Article
- Arginine concentration in arterial vs venous blood in a bleomycin-induced lung inflammation model in mice.PloS one · 2023Article
- Cerebral venous biomarkers and veno-arterial gradients: untapped resources in Alzheimer's disease.Frontiers in neurology · 2023Article
- Integrating transcriptomics, metabolomics, and GWAS helps reveal molecular mechanisms for metabolite levels and disease risk.American journal of human genetics · 2022Article
- Metabolic flux between organs measured by arteriovenous metabolite gradients.Experimental & molecular medicine · 2022Review
- Convergent and Divergent Age Patterning of Gut Microbiota Diversity in Humans and Nonhuman Primates.mSystems · 2022Article
- Microbial Metabolite 3-Indolepropionic Acid Mediates Immunosuppression.Metabolites · 2022Article
- Metabolomics in hepatocellular carcinoma: From biomarker discovery to precision medicine.Frontiers in medical technology · 2022Review
- Integrative analysis of the gut microbiome and metabolome in a rat model with stress induced irritable bowel syndrome.Scientific reports · 2021Article
- Single Quadrupole Multiple Fragment Ion Monitoring Quantitative Mass Spectrometry.Analytical chemistry · 2021Article
- Quantitative flux analysis in mammals.Nature metabolism · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
The human circulatory system consists of arterial blood that delivers nutrients to tissues, and venous blood that removes the metabolic by-products. Although it is well established that arterial blood generally has higher concentrations of glucose and oxygen relative to venous blood, a comprehensive biochemical characterization of arteriovenous differences has not yet been reported. Here we apply cutting-edge, mass spectrometry-based metabolomic technologies to provide a global characterization of metabolites that vary in concentration between the arterial and venous blood of human patients. Global profiling of paired arterial and venous plasma from 20 healthy individuals, followed up by targeted analysis made it possible to measure subtle (<2 fold), yet highly statistically significant and physiologically important differences in water soluble human plasma metabolome. While we detected changes in lactic acid, alanine, glutamine, and glutamate as expected from skeletal muscle activity, a number of unanticipated metabolites were also determined to be significantly altered including Krebs cycle intermediates, amino acids that have not been previously implicated in transport, and a few oxidized fatty acids. This study provides the most comprehensive assessment of metabolic changes in the blood during circulation to date and suggests that such profiling approach may offer new insights into organ homeostasis and organ specific pathology.
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Registered trials
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