ArticleScientific reports2015
Sodium-driven energy conversion for flagellar rotation of the earliest divergent hyperthermophilic bacterium.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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20 citing papers in PubMed, 31 citations in OpenAlex.
- Light-activated cAMP signaling controls sodium-driven motility inProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Cytoplasmic fluidity and the cold life: proteome stability is decoupled from viability in psychrophiles.Nature communications · 2025Article
- Metabolic activity and survival strategies of thermophilic microbiomes during hyperthermophilic composting.mSystems · 2025Article
- Mapping the loss of flagellar motility across the tree of life.The ISME journal · 2025Article
- Ion-Powered Rotary Motors: Where Did They Come from and Where They Are Going?International journal of molecular sciences · 2023Review
- Ancestral reconstruction of the MotA stator subunit reveals that conserved residues far from the pore are required to drive flagellar motility.microLife · 2023Article
- The rapid evolution of flagellar ion selectivity in experimental populations ofScience advances · 2022Article
- Coupling Ion Specificity of the Flagellar Stator Proteins MotA1/MotB1 ofBiomolecules · 2020Article
- The Architectural Dynamics of the Bacterial Flagellar Motor Switch.Biomolecules · 2020Review
- MotP Subunit is Critical for Ion Selectivity and Evolution of a KBiomolecules · 2020Article
- Evolution of the Stator Elements of Rotary Prokaryote Motors.Journal of bacteriology · 2020Review
- Tree of motility - A proposed history of motility systems in the tree of life.Genes to cells : devoted to molecular & cellular mechanisms · 2020Review
- Ancestral Sequence Reconstructions of MotB Are Proton-Motile and Require MotA for Motility.Frontiers in microbiology · 2020Article
- Functional Regulators of Bacterial Flagella.Annual review of microbiology · 2019Review
- The role of conserved charged residues in the bidirectional rotation of the bacterial flagellar motor.MicrobiologyOpen · 2018Article
- COGcollator: a web server for analysis of distant relationships between homologous protein families.Biology direct · 2017Article
- Transcriptional Control of the Lateral-Flagellar Genes of Bradyrhizobium diazoefficiens.Journal of bacteriology · 2017Article
- The tetrameric MotA complex as the core of the flagellar motor stator from hyperthermophilic bacterium.Scientific reports · 2016Article
- A novel type bacterial flagellar motor that can use divalent cations as a coupling ion.Scientific reports · 2016Article
- Nascent chain-monitored remodeling of the Sec machinery for salinity adaptation of marine bacteria.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aquifex aeolicus is a hyperthermophilic, hydrogen-oxidizing and carbon-fixing bacterium that can grow at temperatures up to 95 °C. A. aeolicus has an almost complete set of flagellar genes that are conserved in bacteria. Here we observed that A. aeolicus has polar flagellum and can swim with a speed of 90 μm s(-1) at 85 °C. We expressed the A. aeolicus mot genes (motA and motB), which encode the torque generating stator proteins of the flagellar motor, in a corresponding mot nonmotile mutant of Escherichia coli. Its motility was slightly recovered by expression of A. aeolicus MotA and chimeric MotB whose periplasmic region was replaced with that of E. coli. A point mutation in the A. aeolicus MotA cytoplasmic region remarkably enhanced the motility. Using this system in E. coli, we demonstrate that the A. aeolicus motor is driven by Na(+). As motor proteins from hyperthermophilic bacteria represent the earliest motor proteins in evolution, this study strongly suggests that ancient bacteria used Na(+) for energy coupling of the flagellar motor. The Na(+)-driven flagellar genes might have been laterally transferred from early-branched bacteria into late-branched bacteria and the interaction surfaces of the stator and rotor seem not to change in evolution.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.