ArticleJournal of exercise nutrition & biochemistry2015
Effects of unaccustomed downhill running on muscle damage, oxidative stress, and leukocyte apoptosis.
Article in Journal of exercise nutrition & biochemistry, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Evaluating the Impact of Urolithin A Supplementation on Running Performance, Recovery, and Mitochondrial Biomarkers in Highly Trained Male Distance Runners.Sports medicine (Auckland, N.Z.) · 2025Trial
- The effect of Omega-3 polyunsaturated fatty acid supplementation on exercise-induced muscle damage.Journal of the International Society of Sports Nutrition · 2021Trial
- Ten days of supplementation with a standardizedFrontiers in sports and active living · 2025Article
- Osteocyte Sptbn1 Deficiency Alters Cell Survival and Mechanotransduction Following Formation of Plasma Membrane Disruptions (PMD) from Mechanical Loading.Calcified tissue international · 2024Article
- Repeated Bout Effect of Downhill Running on Physiological Markers of Effort and Post Exercise Perception of Soreness in Trained Female Distance Runners.Sports (Basel, Switzerland) · 2024Article
- Review
- Pre-exercise cryotherapy reduces myoglobin and creatine kinase levels after eccentric muscle stress in young women.Frontiers in physiology · 2024Article
- Pre-exercise hot water immersion increased circulatory heat shock proteins but did not alter muscle damage markers or endurance capacity after eccentric exercise.Temperature (Austin, Tex.) · 2024Article
- Exogenous Ketone Supplementation and Ketogenic Diets for Exercise: Considering the Effect on Skeletal Muscle Metabolism.Nutrients · 2023Review
- MSM Supplementation Is Associated with Reduced Inflammation and Improved Innate Immune Response following In Vitro LPS-Stimulation in Humans after a Bout of Downhill Running.Muscles (Basel, Switzerland) · 2023Article
- Influence of pistachios on force production, subjective ratings of pain, and oxidative stress following exercise-induced muscle damage in moderately trained athletes: A randomized, crossover trial.Metabolism open · 2022Article
- Creatine Kinase and Myoglobin Plasma Levels in Mountain Bike and Road Cyclists 1 h after the Race.International journal of environmental research and public health · 2022Article
- Usnic Acid andAntioxidants (Basel, Switzerland) · 2021Article
- The Effects of Age and Body Fat Content on Post-Downhill Run Recovery Following Whole Body Cryotherapy.International journal of environmental research and public health · 2021Article
- Can Exercise-Induced Muscle Damage Be a Good Model for the Investigation of the Anti-Inflammatory Properties of Diet in Humans?Biomedicines · 2021Review
- Downhill Running: What Are The Effects and How Can We Adapt? A Narrative Review.Sports medicine (Auckland, N.Z.) · 2020Review
- Changes in oxidative stress, inflammation and muscle damage markers following eccentric versus concentric cycling in older adults.European journal of applied physiology · 2019Article
- Fatigue associated with prolonged graded running.European journal of applied physiology · 2016Review
- Neurovascular Compression Caused by Popliteus Muscle Enlargement Without Discrete Trauma.Annals of rehabilitation medicine · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeThe purpose of this study was to investigate the effect of unaccustomed downhill running on muscle damage, oxidative stress, and leukocyte apoptosis.
methodsThirteen moderately trained male subjects performed three 40 min treadmill runs at ~70% VO2max on separate days: a level run (L) followed by two downhill runs (DH1 and DH2). Blood samples were taken at rest (PRE) and immediately (POST), 2 h, 24 h, and 48 h after each run. Data were analyzed using 2-way repeated measures ANOVA with post hoc Tukey tests.
resultsCreatine kinase (CK) activity and oxidative stress level were significantly elevated at 24 h and 48 h following DH1 (P < 0.05). The level of oxidative stress at the POST measurement following DH1 and DH2 was greater than PRE. The rate of leukocyte apoptosis was significantly increased at the POST measurement following all three runs, and remained elevated for up to 48 h following DH1 (P < 0.01).
conclusionCK activity and oxidative stress were elevated following an acute bout of moderate intensity downhill running, resulting in a greater apoptotic response at 24 h and 48 h post-exercise in comparison with level grade running or a second downhill run. These elevations were blunted following DH2. Although the link between exercise-induced muscle damage and leukocyte apoptosis is currently unknown, the differential response to DH1 vs. L and DH2 indicates that it may be mediated by the elevation of oxidative stress.
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