ArticleNutrition research and practice2015
Anti-inflammatory and antioxidant effects of umbelliferone in chronic alcohol-fed rats.
Article in Nutrition research and practice, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- The Chemical Composition and Health-Promoting Effects of theNutrients · 2021Pooled it
- A Comprehensive Review of the Anticancer Activity of Farnesiferol C and Umbelliferone.Anti-cancer agents in medicinal chemistry · 2026Review
- The Natural Defense: Anti-Aging Potential of Plant-Derived Substances and Technological Solutions Against Photoaging.International journal of molecular sciences · 2025Review
- Inhibitory effects of umbelliferone on carbon tetrachloride-induced hepatic fibrosis in rats through the TGF‑β1‑Smad signaling pathway.Molecular medicine reports · 2025Article
- Inhibition of Bone Resorption and Anti-Inflammatory Effect of 7-Hydroxycoumarin in an Animal Model of Lipopolysaccharide-Induced Periodontal Disease.International journal of dentistry · 2025Article
- Coumarin: A natural solution for alleviating inflammatory disorders.Current research in pharmacology and drug discovery · 2024Review
- Proteomic profiling spotlights the molecular targets and the impact of the natural antivirulent umbelliferone on stress response, virulence factors, and the quorum sensing network ofFrontiers in cellular and infection microbiology · 2022Article
- Article
- Phytochemical profiling, in vitro and in vivo anti-inflammatory, analgesic and antipyretic potential of Sesuvium sesuvioides (Fenzl) Verdc. (Aizoaceae).Inflammopharmacology · 2021Article
- Umbelliferone attenuates gentamicin-induced renal toxicity by suppression of TLR-4/NF-κB-p65/NLRP-3 and JAK1/STAT-3 signaling pathways.Environmental science and pollution research international · 2021Article
- The Impact of Acute or Chronic Alcohol Intake on the NF-κB Signaling Pathway in Alcohol-Related Liver Disease.International journal of molecular sciences · 2020Review
- Article
- Coumarins as Modulators of the Keap1/Nrf2/ARE Signaling Pathway.Oxidative medicine and cellular longevity · 2020Review
- Umbelliferone Prevents Lipopolysaccharide-Induced Bone Loss and Suppresses RANKL-Induced Osteoclastogenesis by Attenuating Akt-c-Fos-NFATc1 Signaling.International journal of biological sciences · 2019Article
- Excessive alcohol consumption induces methane production in humans and rats.Scientific reports · 2017Article
- Inhibitory effects of Ponciri Fructus on testosterone-induced benign prostatic hyperplasia in rats.BMC complementary and alternative medicine · 2017Article
- Total Coumarins fromFrontiers in pharmacology · 2017Article
- The Efficacy of Umbelliferone, Arbutin, and N-Acetylcysteine to Prevent Microbial Colonization and Biofilm Development on Urinary Catheter Surface: Results from a Preliminary Study.Journal of pathogens · 2016Article
- Effects of developmental iron deficiency and post-weaning iron repletion on the levels of iron transporter proteins in rats.Nutrition research and practice · 2015Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND/
objectivesInflammation is associated with various types of acute and chronic alcohol liver diseases. In this study, we examined whether umbelliferone (7-hydroxycoumarin, UF) ameliorates chronic alcohol-induced liver damage by modulating inflammatory response and the antioxidant system.
methodsRats were fed a Liber-Decarli liquid diet containing 5% alcohol with or without UF (0.05 g/L) for 8 weeks, while normal rats received an isocaloric carbohydrate liquid diet.
resultsChronic alcohol intake significantly increased serum tumor necrosis factor-α (TNF-α) and interleukin 6 levels and decreased interleukin 10 level; however, UF supplementation reversed the cytokines related to liver damage. UF significantly suppressed hepatic lipopolysaccharide binding protein, toll-like receptor 4 (TLR4), nuclear factor kappa B, and TNF-α gene expression increases in response to chronic alcohol intake. Masson's trichrome staining revealed that UF improved mild hepatic fibrosis caused by alcohol, and UF also significantly increased the mRNA expressions and activities of superoxide dismutase and catalase in liver, and thus, decreased lipid peroxide and mitochondrial hydrogen peroxide levels.
conclusionsThe findings of this study indicate that UF protects against alcohol-induced liver damage by inhibiting the TLR4 signaling pathway and activating the antioxidant system.
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