Evidence map›Paper›PMID 26244052›Full record

ArticleInfectious agents and cancer2015

HPV infection and cervical neoplasia: associated risk factors.

Andrea Alves Ribeiro, Maria Cecília Costa, Rosane Ribeiro Figueiredo Alves, Luísa Lina Villa, Vera Aparecida Saddi, Megmar Aparecida Dos Santos Carneiro, Luiz Carlos Zeferino, Sílvia Helena Rabelo-Santos

2 registry-linked trialsAbstract read
In one paragraph

Article in Infectious agents and cancer, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07211204 nawithdrawnnot on this mapstarted 2026, after this paper: background citation

Study To Compare The Efficacy Of Cervical Cytology With Molecular Screening In The Detection Of Reactive Cellular Changes In The Cervix In An Open Population

TypeinterventionalSponsorTimser SAPI de CVRan2026 to 2026Enrolled0ConditionsAtypical Squamous Cell of Undetermined Significance, ASC-US, Atypical Glandular Cells of Uncertain Significance, AGUSArmsPhysical examination, Liquid-based cytology, Molecular screening, HPV DNA test, Colposcopy
NCT07480902 narecruitingnot on this mapstarted 2026, after this paper: background citation

Study To Compare The Efficacy Of Cervical Cytology With Molecular Screening For Detecting Reactive Cellular Changes In The Cervix In An Open Population

TypeinterventionalSponsorTimser SAPI de CVRan2026 to 2026Enrolled558ConditionsI) Atypical Squamous Cells of Undetermined Significance (ASC-US), II) Atypical Glandular Cells of Uncertain Significance (AGUS), III) Cervical Intraepithelial Neoplasia (CIN), CIN-1, CIN-2, CIN-3, IV) Low-grade Squamous Intraepithelial Lesion (LSIL)ArmsPhysical examination, Liquid-based cytology, Molecular screening, HPV DNA test, Colposcopy
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  8. Review
  9. Vulvar squamous cell carcinoma due to human papillomavirus type 11.Skin research and technology : official journal of International Society for Bioengineering and the Skin (ISBS) [and] International Society for Digital Imaging of Skin (ISDIS) [and] International Society for Skin Imaging (ISSI) · 2023
    Article
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  13. Facilitators and Barriers of HPV Vaccine Acceptance, Initiation, and Completion among LGBTQ Community in the U.S.: A Systematic Review.International journal of sexual health : official journal of the World Association for Sexual Health · 2022
    Article
  14. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Andrea Alves RibeiroInstitute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO Brazil ; Pontifical Catholic University of Goiás, Goiânia, GO Brazil.
Maria Cecília CostaSanta Casa de São Paulo, INCT-HPV at Santa Casa Research Institute, School of Medicine, São Paulo, Brazil.
Rosane Ribeiro Figueiredo AlvesSanta Casa de Misericórdia de Goiânia, Goiânia, GO Brazil ; Pontifical Catholic University of Goiás, Goiânia, GO Brazil ; School of Medicine, Federal University of Goiás, Goiânia, GO Brazil.
Luísa Lina VillaSanta Casa de São Paulo, INCT-HPV at Santa Casa Research Institute, School of Medicine, São Paulo, Brazil ; Department of Radiology and Oncology, School of Medicine, University of São Paulo and Cancer Institute of the State of São Paulo, ICESP, São Paulo, Brazil.
Vera Aparecida SaddiPontifical Catholic University of Goiás, Goiânia, GO Brazil ; Program in Environmental Sciences and Health, Pontifical Catholic University of Goiás, Goiânia, GO Brazil ; Laboratory of Oncogenetics and Radiology, Associação de Combate ao Câncer, Goiás, Goiânia, GO Brazil.
Megmar Aparecida Dos Santos CarneiroInstitute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO Brazil.
Luiz Carlos ZeferinoState University of Campinas (UNICAMP), Campinas, SP Brazil.
Sílvia Helena Rabelo-SantosInstitute of Tropical Pathology and Public Health, Federal University of Goiás, Goiânia, GO Brazil ; School of Pharmacy, Federal University of Goiás, Goiânia, GO Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBehavioral risks such as age at first sexual intercourse, number of sexual partners and partner's sexual behavior are associated with an increased risk of HPV infection, persistence of the infection and the development of neoplastic precursor lesions. The objective of this study was to evaluate the risk factors associated with HPV positivity and with a diagnosis of cervical neoplasia in women referred with an abnormal cervical smear.

methodsThis study evaluated a series of 198 women referred with an abnormal cervical smear. Risk factors for HPV infection were investigated using a questionnaire. All cervical specimens were tested for 27 HPV genotypes using the Roche polymerase chain reaction reverse line blot assay.

resultsThe overall prevalence of HPV was 87 %. First sexual intercourse before 16 years of age was significantly associated with a positive HPV test (OR 4.41; 95 %CI: 1.20 - 19.33; p = 0.01). A significant association was also found between this risk factor and CIN 1 lesions or worse (OR 2.2; 95 %CI 0.94 - 5.08; p = 0.03).

conclusionsThe age at which a woman begins to be sexually active is associated with HPV infection and with a diagnosis of cervical neoplasia.

Indexed as

Abnormal cervical smearHuman papillomavirusRisk factors

Identifiers

PMID26244052
PMCPMC4524198

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.