ArticleDevelopment (Cambridge, England)2015
Yap and Taz are required for Ret-dependent urinary tract morphogenesis.
Article in Development (Cambridge, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 49 citations in OpenAlex.
- Coordinated Hippo, IFN and NF-κB pathway activation in kidney rejection.Open medicine (Warsaw, Poland) · 2026Article
- Ureter development and associated congenital anomalies.Nature reviews. Nephrology · 2025Review
- DNA-damage induced cell death ineLife · 2022Article
- Novel zebrafish polycystic kidney disease models reveal functions of the Hippo pathway in renal cystogenesis.Disease models & mechanisms · 2021Article
- Nuclear exclusion of YAP exacerbates podocyte apoptosis and disease progression in Adriamycin-induced focal segmental glomerulosclerosis.Laboratory investigation; a journal of technical methods and pathology · 2021Article
- YAP/TAZ Are Required to Suppress Osteogenic Differentiation of Vascular Smooth Muscle Cells.iScience · 2020Article
- Control of skeletal morphogenesis by the Hippo-YAP/TAZ pathway.Development (Cambridge, England) · 2020Article
- Inhibition of Yes-Associated Protein by Verteporfin Ameliorates Unilateral Ureteral Obstruction-Induced Renal Tubulointerstitial Inflammation and Fibrosis.International journal of molecular sciences · 2020Article
- Mask, a component of the Hippo pathway, is required for Drosophila eye morphogenesis.Developmental biology · 2020Article
- Guiding Cell Network Assembly using Shape-Morphing Hydrogels.Advanced materials (Deerfield Beach, Fla.) · 2020Article
- Tubule-Specific Mst1/2 Deficiency Induces CKDJournal of the American Society of Nephrology : JASN · 2020Article
- Tubular MST1/2 Deletion and Renal Fibrosis.Journal of the American Society of Nephrology : JASN · 2020Article
- Article
- Gen1 Modulates Metanephric Morphology Through Retinoic Acid Signaling.DNA and cell biology · 2019Article
- Immunofluorescence Microscopy to Study Endogenous TAZ in Mammalian Cells.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Yap regulates glucose utilization and sustains nucleotide synthesis to enable organ growth.The EMBO journal · 2018Article
- Article
- Reciprocal Spatiotemporally Controlled Apoptosis Regulates Wolffian Duct Cloaca Fusion.Journal of the American Society of Nephrology : JASN · 2018Article
- Emerging role of Hippo signalling pathway in bladder cancer.Journal of cellular and molecular medicine · 2018Review
- YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation.The Journal of clinical investigation · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
Despite the high occurrence of congenital abnormalities of the lower urinary tract in humans, the molecular, cellular and morphological aspects of their development are still poorly understood. Here, we use a conditional knockout approach to inactivate within the nephric duct (ND) lineage the two effectors of the Hippo pathway, Yap and Taz. Deletion of Yap leads to hydronephrotic kidneys with blind-ending megaureters at birth. In Yap mutants, the ND successfully migrates towards, and contacts, the cloaca. However, close analysis reveals that the tip of the Yap(-/-) ND forms an aberrant connection with the cloaca and does not properly insert into the cloaca, leading to later detachment of the ND from the cloaca. Taz deletion from the ND does not cause any defect, but analysis of Yap(-/-);Taz(-/-) NDs indicates that both genes play partially redundant roles in ureterovesical junction formation. Aspects of the Yap(-/-) phenotype resemble hypersensitivity to RET signaling, including excess budding of the ND, increased phospho-ERK and increased expression of Crlf1, Sprouty1, Etv4 and Etv5. Importantly, the Yap(ND) (-/-) ND phenotype can be largely rescued by reducing Ret gene dosage. Taken together, these results suggest that disrupting Yap/Taz activities enhances Ret pathway activity and contributes to pathogenesis of lower urinary tract defects in human infants.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.