ArticlePlant physiology2015
An Ancestral Role for CONSTITUTIVE TRIPLE RESPONSE1 Proteins in Both Ethylene and Abscisic Acid Signaling.
Article in Plant physiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 51 citations in OpenAlex.
- A RAF-SnRK2-PP2C functional module regulates cell survival in the chlorophyte Chlamydomonas reinhardtii.The New phytologist · 2026Article
- Desiccation Tolerance in Moss and Liverwort: Insights into the Evolutionary Mechanisms of Terrestrialization.International journal of molecular sciences · 2026Review
- ETHYLENE INSENSITIVE2-like protein mediates submergence and drought responses in Physcomitrium patens.Plant physiology · 2025Article
- Illumina-based transcriptomic analysis of the fast-growing leguminous treeFrontiers in plant science · 2024Article
- Plant hormone regulation of abiotic stress responses.Nature reviews. Molecular cell biology · 2022Review
- Red Light and Glucose Enhance Cytokinin-Mediated Bud Initial Formation inPlants (Basel, Switzerland) · 2022Article
- Phytohormone biosynthesis and signaling pathways of mosses.Plant molecular biology · 2021Review
- Article
- Growth Promotion or Osmotic Stress Response: How SNF1-Related Protein Kinase 2 (SnRK2) Kinases Are Activated and Manage Intracellular Signaling in Plants.Plants (Basel, Switzerland) · 2021Review
- Initiation and amplification of SnRK2 activation in abscisic acid signaling.Nature communications · 2021Article
- Cellular Phosphorylation Signaling and Gene Expression in Drought Stress Responses: ABA-Dependent and ABA-Independent Regulatory Systems.Plants (Basel, Switzerland) · 2021Review
- Activation of SnRK2 by Raf-like kinase ARK represents a primary mechanism of ABA and abiotic stress responses.Plant physiology · 2021Article
- Essential Roles of the Linker Sequence Between Tetratricopeptide Repeat Motifs of Ethylene Overproduction 1 in Ethylene Biosynthesis.Frontiers in plant science · 2021Article
- Role of Raf-like kinases in SnRK2 activation and osmotic stress response in plants.Nature communications · 2020Review
- Arabidopsis Raf-like kinases act as positive regulators of subclass III SnRK2 in osmostress signaling.The Plant journal : for cell and molecular biology · 2020Article
- Ethylene signaling in plants.The Journal of biological chemistry · 2020Review
- Evolution of Abscisic Acid Signaling Module and Its Perception.Frontiers in plant science · 2020Review
- SnRK2 protein kinases represent an ancient system in plants for adaptation to a terrestrial environment.Communications biology · 2019Article
- Plant Hormone Signaling Crosstalks between Biotic and Abiotic Stress Responses.International journal of molecular sciences · 2018Review
- Ethylene Receptors Signal via a Noncanonical Pathway to Regulate Abscisic Acid Responses.Plant physiology · 2018Article
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Authors and funding
6 authors at 1 institution in 3 countries.
Funding
Abstract
Land plants have evolved adaptive regulatory mechanisms enabling the survival of environmental stresses associated with terrestrial life. Here, we focus on the evolution of the regulatory CONSTITUTIVE TRIPLE RESPONSE1 (CTR1) component of the ethylene signaling pathway that modulates stress-related changes in plant growth and development. First, we compare CTR1-like proteins from a bryophyte, Physcomitrella patens (representative of early divergent land plants), with those of more recently diverged lycophyte and angiosperm species (including Arabidopsis [Arabidopsis thaliana]) and identify a monophyletic CTR1 family. The fully sequenced P. patens genome encodes only a single member of this family (PpCTR1L). Next, we compare the functions of PpCTR1L with that of related angiosperm proteins. We show that, like angiosperm CTR1 proteins (e.g. AtCTR1 of Arabidopsis), PpCTR1L modulates downstream ethylene signaling via direct interaction with ethylene receptors. These functions, therefore, likely predate the divergence of the bryophytes from the land-plant lineage. However, we also show that PpCTR1L unexpectedly has dual functions and additionally modulates abscisic acid (ABA) signaling. In contrast, while AtCTR1 lacks detectable ABA signaling functions, Arabidopsis has during evolution acquired another homolog that is functionally distinct from AtCTR1. In conclusion, the roles of CTR1-related proteins appear to have functionally diversified during land-plant evolution, and angiosperm CTR1-related proteins appear to have lost an ancestral ABA signaling function. Our study provides new insights into how molecular events such as gene duplication and functional differentiation may have contributed to the adaptive evolution of regulatory mechanisms in plants.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.