ArticleJournal of veterinary science2015
Stress and pain response after oligofructose induced-lameness in dairy heifers.
Article in Journal of veterinary science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 55 citations in OpenAlex.
- A systematic review of the utility of biomarkers as aids in the early diagnosis and outcome prediction of bovine respiratory disease complex in feedlot cattle.Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2022Pooled it
- Substance P concentrations in the blood plasma and serum of adult cattle and calves during different painful procedures and conditions - a systematic review.BMC veterinary research · 2022Pooled it
- Comparison of serum cortisol concentrations as indicators of the perioperative stress response in cows undergoing correction of left displaced abomasum by right flank laparotomy with omentopexy versus left flank laparoscopy with abomasopexy.Veterinary and animal science · 2026Article
- A pilot study on the effects of preventive hoof trimming on acute stress and behavioral parameters in non-lame dairy cows.Journal of advanced veterinary and animal research · 2026Article
- Influence of a repeated peripheral electrical stimulation on substance P and cortisol concentrations, and behavior in German Simmental calves - a pilot study.Frontiers in veterinary science · 2026Article
- Biotinidase as a novel biomarker for pain assessment in dairy cattle.Pain reports · 2025Article
- Pilot Study: Exploring the Feasibility of Individual Voluntary Waiting Period Settings Using Postpartum Recovery Indicators in Dairy Cows.Animals : an open access journal from MDPI · 2025Article
- Observational study evaluating the association of hoof trimming with dairy cattle behavior and milk yield in Canada and the United Kingdom.JDS communications · 2024Article
- Lameness in Cattle-Etiopathogenesis, Prevention and Treatment.Animals : an open access journal from MDPI · 2024Review
- Pain pathophysiology and pharmacology of cattle: how improved understanding can enhance pain prevention, mitigation, and welfare.Frontiers in pain research (Lausanne, Switzerland) · 2024Review
- Evaluation of Substance P concentrations in the blood plasma of jugular and tail vein of healthy German Simmental cows.BMC veterinary research · 2023Article
- Evaluation of Substance P as a New Stress Parameter in Horses in a Stress Model Involving Four Different Stress Levels.Animals : an open access journal from MDPI · 2023Article
- Combining accelerometers and direct visual observations to detect sickness and pain in cows of different ages submitted to systemic inflammation.Scientific reports · 2023Article
- Association between Milk Electrical Conductivity Biomarkers with Lameness in Dairy Cows.Veterinary sciences · 2023Article
- Welfare traits of Bos indicus cattle castrated immunologically and fed beta-adrenergic agonists.Animal bioscience · 2021Article
- Methods for Pain Assessment in Calves and Their Use for the Evaluation of Pain during Different Procedures-A Review.Animals : an open access journal from MDPI · 2021Review
- Changes in Saliva Analytes Associated with Lameness in Cows: A Pilot Study.Animals : an open access journal from MDPI · 2020Article
- Characterization of Oligofructose-Induced Acute Rumen Lactic Acidosis and the Appearance of Laminitis in Zebu Cattle.Animals : an open access journal from MDPI · 2020Article
- Dynamic ROS Production and Gene Expression of Heifers Blood Neutrophil in a Oligofructose Overload Model.Frontiers in veterinary science · 2020Article
- Spinal Reactive Oxygen Species and Oxidative Damage Mediate Chronic Pain in Lame Dairy Cows.Animals : an open access journal from MDPI · 2019Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lameness is one of the most painful conditions that affects dairy cattle. This study was conducted to evaluate clinical signs and plasma concentration of several pain and stress biomarkers after oligofructose-induced lameness in dairy heifers. Lameness was induced using an oligofructose overload model in 12 non-pregnant heifers. Clinical parameters and blood samples were obtained at 48 and 24 h and at 6, 12, 24, 36 and 48 h after induction of lameness. Clinical parameters included heart rate, respiratory rate, ruminal frequency and lameness score. Plasma biomarkers included cortisol, haptoglobin, norepinephrine, beta-endorphin and substance P. Differences were observed in all parameters between control and treated heifers. The plasma concentration of biomarkers increased significantly in treated animals starting 6 h after induction of lameness, reaching maximum levels at 24 h for cortisol, 48 h for haptoglobin, 6 h for norepinephrine, 12 h for substance P and at 24 h for beta-endorphin. Overall, our results confirm that lameness associated pain induced using the oligofructose model induced changes in clinical parameters and plasma biomarkers of pain and stress in dairy heifers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.