Evidence map›Paper›PMID 26243472›Full record

ArticleInternational journal of colorectal disease2015

Association of dialysis with adverse postoperative outcomes in colorectal cancer-an analysis of ACS-NSQIP.

Wan-Hsiang Hu, Luis Carlos Cajas-Monson, Samuel Eisenstein, Lisa Parry, Sonia Ramamoorthy

Abstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in International journal of colorectal disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
1.1field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it, 26 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Wan-Hsiang HuDepartment of Surgery and Moores Cancer Center, School of Medicine, University of California, San Diego Health System, La Jolla, CA, USA.
Luis Carlos Cajas-MonsonDepartment of Surgery and Moores Cancer Center, School of Medicine, University of California, San Diego Health System, La Jolla, CA, USA.
Samuel EisensteinDepartment of Surgery and Moores Cancer Center, School of Medicine, University of California, San Diego Health System, La Jolla, CA, USA.
Lisa ParryDepartment of Surgery and Moores Cancer Center, School of Medicine, University of California, San Diego Health System, La Jolla, CA, USA.
Sonia RamamoorthyDepartment of Surgery and Moores Cancer Center, School of Medicine, University of California, San Diego Health System, La Jolla, CA, USA. sramamoorthy@mail.ucsd.edu.
University of California, San Diego · USUC San Diego Health System · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDialysis is an important factor in predicting the risk associated with cardiovascular and general abdominal surgery. The association between cancer patients and dialysis was also studied, and in particular, the effects of dialysis on the postoperative outcomes of colorectal cancer which has not been widely reported in the literature.

methodsThis is a retrospective, multi-institutional study of the American College of Surgeons-National Surgical Quality Improvement Program (ACS-NSQIP) database, investigating preoperative dialysis status and its association with postoperative mortality and morbidity.

resultsAmong 42,403 colorectal cancer patients, 265 patients (0.6 %) were receiving dialysis. Patients undergoing dialysis had a higher risk of re-intubation (6.8 %, p < 0.001), on ventilator-support more than 48 h (7.2 %, p < 0.001), and sepsis (7.2 %, p < 0.05). Deep surgical site infection (adjusted odds ratio = 2.09), pneumonia (adjusted odds ratio = 1.86), and septic shock (adjusted odds ratio = 1.9) were significantly associated with dialysis status. The postoperative mortality rate of dialysis patients was 8.3 % (p < 0.001) and had significant association in a multivariate Cox proportional hazard model (hazard ratio = 1.63, p = 0.026). Total length of hospital stay (coefficient = 3.5, p < 0.001) and overall complication (coefficient = 0.134, p < 0.001) were prominent in the dialysis groups. The rate of laparoscopic surgery in dialysis and non-dialysis patients was 33 and 42 %, respectively (odds ratio = 0.693, p = 0.005).

conclusionsIn colorectal cancer, dialysis status significantly contributes to postoperative morbidity, length of total hospital stay, and mortality. In addition, the rates of preventable infection and pulmonary complications were shown to require more careful attention in the hospital setting, and particularly in dialysis patients. Preoperative dialysis patients are less likely than non-dialysis patients to undergo a minimally invasive approach.

Indexed as

Postoperative ComplicationsRenal DialysisAdultAgedAged, 80 and overColorectal NeoplasmsFemaleHumansKidney Failure, ChronicLength of StayMaleMiddle AgedProportional Hazards ModelsRegression AnalysisRetrospective StudiesRisk FactorsColorectal cancerDialysisPostoperative morbidityPostoperative mortality

Identifiers

PMID26243472
OpenAlexW2197798944

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.