Evidence map›Paper›PMID 26243359›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016

Serum chitotriosidase in postmenopausal women with severe osteoporosis.

M Musumeci, A Palermo, L D'Onofrio, G Vadalà, V Greto, E Di Stasio, E Maddaloni, M Di Rosa, D Tibullo, S Angeletti and 4 more

Erratum issuedAbstract read
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In one paragraph

Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

14 authors at 3 institutions in 1 country.

M MusumeciClinical Pathology and Microbiology Laboratory, University Campus Bio-Medico, Rome, Italy.
A PalermoDepartment of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo, 21 - 00128, Rome, Italy. a.palermo@unicampus.it.
L D'OnofrioDepartment of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo, 21 - 00128, Rome, Italy.
G VadalàDepartment of Orthopaedic surgery, University Campus Bio-Medico, Rome, Italy.
V GretoDepartment of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo, 21 - 00128, Rome, Italy.
E Di StasioInstitute of Biochemistry and clinical Biochemistry, University Cattolica del Sacro Cuore, Rome, Italy.
E MaddaloniDepartment of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo, 21 - 00128, Rome, Italy.
M Di RosaDepartment of Bio-medical Sciences, University of Catania, Catania, Italy.
D TibulloDepartment of Clinical and Molecular Biomedicine, University of Catania, Ospedale Ferrarotto, Catania, Italy.
S Angeletti
A SilviaClinical Pathology and Microbiology Laboratory, University Campus Bio-Medico, Rome, Italy.
N NapoliDepartment of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo, 21 - 00128, Rome, Italy.
V DenaroDepartment of Orthopaedic surgery, University Campus Bio-Medico, Rome, Italy.
S ManfriniDepartment of Endocrinology and Diabetes, University Campus Bio-Medico, Via Alvaro del Portillo, 21 - 00128, Rome, Italy.
Università Campus Bio-Medico · ITUniversity of Catania · ITUniversità Cattolica del Sacro Cuore · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledHuman chitotriosidase (Chit) increases during the osteoclast differentiation and their activity. We demonstrated that serum Chit was significantly higher in osteoporotic subjects than in healthy control ones and revealed a negative correlation between Chit and bone mineral density (BMD). This is the first study showing a correlation between Chit and severe postmenopausal osteoporosis.

introductionMammalian chitinases exert important biological roles in the monocyte lineage and chronic inflammatory diseases. In particular, Chit seems to promote bone resorption in vitro. No in vivo studies have been performed to confirm this finding. We aim to evaluate Chit activity in postmenopausal women affected by severe osteoporosis.

methodsIn this cross-sectional study, 91 postmenopausal women affected by osteoporosis and 61 with either osteopenia or normal BMD were screened. All subjects were assessed by dual-energy X-ray absorptiometry (DXA) and X-ray vertebral morphometry. Osteoporotic subjects were considered eligible if they were affected by at least one vertebral osteoporotic fracture (group A = 57 subjects). Osteopenic or healthy subjects were free from osteoporotic fractures (group B = 51 subjects). Enzymatic Chit and serum β-CrossLaps (CTX) were measured in the whole population.

resultsGroup A showed higher serum levels of beta-CTX compared to group B (0.40 ± 0.26 ng/mL vs 0.29 ± 0.2 ng/mL, p = 0.022). Chit was significantly higher in group A than in group B (1042 ± 613 nmol/mL/h vs 472 ± 313 nmol/mL/h, p < 0.001, respectively) even after adjustment for age (p < 0.001). Spearman correlation test revealed a negative correlation between Chit and BMD at each site (lumbar spine: r = -0.38, p = 0.001, femoral neck: r = -0.35, p = 0.001, total femur: r = -0.39, p < 0.001). Furthermore, a positive correlation between Chit and PTH was observed (r = 0.26, p = 0.013). No significant correlation was found between Chit and beta-CTX (r = 0.12, p = 0.229). After a multivariate analysis, a positive correlation between severe osteoporosis and Chit (p < 0.001), beta-CTX (p = 0.013), and age (p < 0.001) was observed.

conclusionThis is the first clinical study showing a correlation between Chit and severe postmenopausal osteoporosis. Larger and prospective studies are needed to evaluate if Chit may be a promising clinical biomarker and/or therapeutic monitor in subjects with osteoporosis.

Indexed as

Absorptiometry, PhotonAgedAged, 80 and overBiomarkersBone DensityCase-Control StudiesClinical Enzyme TestsCross-Sectional StudiesFemaleFemurHexosaminidasesHumansLumbar VertebraeMiddle AgedOsteoporosis, PostmenopausalOsteoporotic FracturesBiomarkerschitotriosidaseHexosaminidasesChitotriosidaseFractureOsteoporosisSerum CTX

Identifiers

PMID26243359
OpenAlexW2175419130

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.