ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2016
Relationship of sarcopenia and body composition with osteoporosis.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers, 7 of them syntheses that pooled it.
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The trial behind it
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Who cites it
126 citing papers in PubMed, 7 syntheses or guidelines pooled it, 204 citations in OpenAlex.
- Multi-ancestry whole genome sequencing analysis of lean body mass.Genome biology · 2025Pooled it
- The impact of sarcopenia on the incidence of postoperative outcomes following spine surgery: Systematic review and meta-analysis.PloS one · 2024Pooled it
- A multiethnic whole genome sequencing study to identify novel loci for bone mineral density.Human molecular genetics · 2022Pooled it
- The Effects of Football Practice on Nutritional Status and Body Composition in Children: A Systematic Review and Meta-Analysis.Nutrients · 2021Pooled it
- Sex Differences in Adaptations in Muscle Strength and Size Following Resistance Training in Older Adults: A Systematic Review and Meta-analysis.Sports medicine (Auckland, N.Z.) · 2021Pooled it
- Pooled it
- Systematic review and meta-analysis of prevalence of sarcopenia in post acute inpatient rehabilitation.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2018Pooled it
- Effects of Extra Virgin Olive Oil (EVOO) and the Traditional Brazilian Diet on Sarcopenia in Severe Obesity: A Randomized Clinical Trial.Nutrients · 2020Trial
- Independent Associations of Appendicular Skeletal Muscle Mass Index and Waist Circumference with Site-Specific Bone Mineral Density in Postmenopausal Women: A Real-World Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2026Article
- Bone Loss, Osteoporosis, and Skeletal Fragility: Hidden Consequences of Cancer Cachexia.Cells · 2026Review
- Toe Grasp Strength and Its Association with Muscle Mass and Calcaneal Bone Status in Young Adults: A Cross-Sectional Study.Journal of musculoskeletal & neuronal interactions · 2026Article
- Why Osteosarcopenia Matters: Clinical and Investigative Implications.European journal of clinical investigation · 2026Review
- Article
- Orthogeriatric Fracture Syndrome: A Large-Scale Bibliometric Analysis of a Proposed Concept for Cross-Disciplinary Awareness and Coordinated Care.Journal of clinical medicine · 2026Article
- Associations of magnesium intake and a magnesium-rich diet score with sarcopenia in middle-aged and older Korean adults: potential mediation by C-reactive protein.Frontiers in nutrition · 2026Article
- The protective role of appendicular lean mass in osteoporosis development among postmenopausal type 2 diabetes patients.Scientific reports · 2025Article
- Development and validation of a nomogram for osteoporosis based on clinical characteristics in Kunming.Journal of orthopaedic surgery and research · 2025Article
- The association between personal-social characteristics with bone mineral density in postmenopausal women with primary osteoporosis.Scientific reports · 2025Article
- Crosstalk between osteoporosis and fat-infiltrated psoas at the upper lumbar levels.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
- Comparison of paravertebral muscle thickness and fatty infiltration in patients with osteoporosis, osteopenia and normal bone mineral density: a single-blind retrospective controlled trial.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2025Article
66 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
unlabelledThe purpose of the study is to investigate the relationship between sarcopenia and body composition and osteoporosis in cohorts of three different races with a total of 17,891 subjects. Lean mass and grip strength were positively associated with bone mineral densities (BMDs). Subjects with sarcopenia were two times more likely to have osteoporosis compared with normal subjects.
introductionThe relationship between sarcopenia and osteoporosis is not totally clear. First, the present study assessed this relationship by using two different definitions for sarcopenia. Second, we examined the associations of body composition (including muscle mass as a major and important component) and muscle strength on regional and whole-body BMDs.
methodsIn total, 17,891 subjects of African American, Caucasian, and Chinese ethnicities were analyzed. Sarcopenia was defined by relative appendicular skeletal muscle mass (RASM) cut points and also by the definition of the European Working Group on Sarcopenia in Older People (low RASM plus low muscle function). Multiple regression analyses were conducted to examine the association of fat mass, lean mass (including muscle mass), and grip strength with regional and whole-body BMDs. Multivariate logistic regression analysis was performed to explore the association between sarcopenia and osteopenia/osteoporosis.
resultsBMDs were positively associated with lean mass and negatively associated with fat mass, after controlling for potential confounders. Grip strength was significantly associated with higher BMDs. Each standard deviation (SD) increase in RASM resulted in a ~37 % reduction in risk of osteopenia/osteoporosis (odds ratio (OR) = 0.63; 95 % confidence interval (CI) = 0.59, 0.66). Subjects with sarcopenia defined by RASM were two times more likely to have osteopenia/osteoporosis compared with the normal subjects (OR = 2.04; 95 % CI = 1.61, 2.60). Similarly, subjects with sarcopenia (low muscle mass and low grip strength) were ~1.8 times more likely to have osteopenia/osteoporosis than normal subjects (OR = 1.87; 95 % CI = 1.09, 3.20).
conclusionsHigh lean mass and muscle strength were positively associated with BMDs. Sarcopenia is associated with low BMD and osteoporosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.