Evidence map›Paper›PMID 26243314›Full record

ArticleThe Plant cell2015

Brassinosteroids Are Master Regulators of Gibberellin Biosynthesis in Arabidopsis.

Simon J Unterholzner, Wilfried Rozhon, Michael Papacek, Jennifer Ciomas, Theo Lange, Karl G Kugler, Klaus F Mayer, Tobias Sieberer, Brigitte Poppenberger

Open access · greenAbstract read
In one paragraph

Article in The Plant cell, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 100 papers.

0numbers the graph read from it
0cells of the map it votes in
100citing papers in PubMed
31.0field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

100 citing papers in PubMed, 234 citations in OpenAlex.

  1. Towards an integrated molecular understanding of plant hormones.Journal of integrative plant biology · 2026
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  6. Exploration of the signaling pathway involving OsCSN8 in regulating the leaf angle of rice.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2026
    Article
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40 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Simon J UnterholznerBiotechnology of Horticultural Crops, TUM School of Life Sciences Weihenstephan, Technische Universität München, D-85354 Freising, Germany.
Wilfried RozhonBiotechnology of Horticultural Crops, TUM School of Life Sciences Weihenstephan, Technische Universität München, D-85354 Freising, Germany.
Michael PapacekBiotechnology of Horticultural Crops, TUM School of Life Sciences Weihenstephan, Technische Universität München, D-85354 Freising, Germany.ORCID http://orcid.org/0000-0001-9669-9319
Jennifer CiomasBiotechnology of Horticultural Crops, TUM School of Life Sciences Weihenstephan, Technische Universität München, D-85354 Freising, Germany.
Theo LangeInstitute of Plant Biology, Technical University of Braunschweig, D-38106 Braunschweig, Germany.ORCID http://orcid.org/0000-0003-1294-2647
Karl G KuglerPlant Genome and System Biology, Helmholtz Center Munich, D-85764 Neuherberg, Germany.ORCID http://orcid.org/0000-0003-2342-7472
Klaus F MayerPlant Genome and System Biology, Helmholtz Center Munich, D-85764 Neuherberg, Germany.
Tobias SiebererPlant Growth Regulation, TUM School of Life Sciences Weihenstephan, Technische Universität München, D-85354 Freising, Germany.
Brigitte PoppenbergerBiotechnology of Horticultural Crops, TUM School of Life Sciences Weihenstephan, Technische Universität München, D-85354 Freising, Germany brigitte.poppenberger@wzw.tum.de.ORCID http://orcid.org/0000-0003-1020-0500
Technical University of Munich · DEHelmholtz Zentrum München · DETechnische Universität Braunschweig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Plant growth and development are highly regulated processes that are coordinated by hormones including the brassinosteroids (BRs), a group of steroids with structural similarity to steroid hormones of mammals. Although it is well understood how BRs are produced and how their signals are transduced, BR targets, which directly confer the hormone's growth-promoting effects, have remained largely elusive. Here, we show that BRs regulate the biosynthesis of gibberellins (GAs), another class of growth-promoting hormones, in Arabidopsis thaliana. We reveal that Arabidopsis mutants deficient in BR signaling are severely impaired in the production of bioactive GA, which is correlated with defective GA biosynthetic gene expression. Expression of the key GA biosynthesis gene GA20ox1 in the BR signaling mutant bri1-301 rescues many of its developmental defects. We provide evidence that supports a model in which the BR-regulated transcription factor BES1 binds to a regulatory element in promoters of GA biosynthesis genes in a BR-induced manner to control their expression. In summary, our study underscores a role of BRs as master regulators of GA biosynthesis and shows that this function is of major relevance for the growth and development of vascular plants.

Indexed as

ArabidopsisArabidopsis ProteinsBrassinosteroidsDNA-Binding ProteinsFlowersGene Expression Regulation, DevelopmentalGene Expression Regulation, PlantGibberellinsHypocotylImmunoblottingMixed Function OxygenasesMutationNuclear ProteinsPlant Growth RegulatorsPlants, Genetically ModifiedPromoter Regions, GeneticArabidopsis ProteinsBES1 protein, ArabidopsisBrassinosteroidsBRI1 protein, ArabidopsisDNA-Binding Proteinsgibberellin 20 oxidase 1, ArabidopsisGibberellinsMixed Function OxygenasesNuclear ProteinsPlant Growth RegulatorsProtein Kinases

Identifiers

PMID26243314
PMCPMC4568508
OpenAlexW2112132633

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.