Evidence map›Paper›PMID 26243216›Full record

ArticleThe journals of gerontology. Series A, Biological sciences and medical sciences2016

The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging.

Warren Ladiges, Yuji Ikeno, Laura Niedernhofer, Richard A McIndoe, Marcia A Ciol, Jerry Ritchey, Denny Liggitt

Abstract read
In one paragraph

Article in The journals of gerontology. Series A, Biological sciences and medical sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Geropathology. An inside view of biological aging.Aging pathobiology and therapeutics · 2022
    Article
  5. Study of Longitudinal Aging in Mice: Presentation of Experimental Techniques.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021
    Article
  6. Article
  7. Article
  8. Article
  9. Testing drug combinations to slow aging.Pathobiology of aging & age related diseases · 2018
    Article
  10. Heterogeneity of Human Aging and Its Assessment.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Article
  11. A New Preclinical Paradigm for Testing Anti-Aging Therapeutics.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017
    Article
  12. The emerging role of geropathology in preclinical aging studies.Pathobiology of aging & age related diseases · 2017
    Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors.

Warren LadigesDepartment of Comparative Medicine, University of Washington, Seattle. wladiges@u.washington.edu.
Yuji IkenoDepartment of Pathology, University of Texas at San Antonio, San Antonio.
Laura NiedernhoferDepartment of Metabolism and Aging, Scripps Florida, Jupiter.
Richard A McIndoeDepartment of Bioinformatics, Georgia Regents University, Augusta.
Marcia A CiolDepartment of Rehabilitation Medicine, University of Washington, Seattle.
Jerry RitcheyDepartment of Veterinary Pathology, College of Veterinary Medicine, Oklahoma State University, Stillwater.
Denny LiggittDepartment of Comparative Medicine, University of Washington, Seattle.

Funding

TRANSGENIC COREP30AG013319 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI JAMES FLOYD NELSON · 1995 to 2026
$30.6M
San Antonio OAIC - Research Education Component (REC)P30AG044271 · NIA · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Adam Salmon · 2015 to 2026
$14.1M
Pathology of Aging Research NetworkR24AG047115 · NIA · UNIVERSITY OF WASHINGTON · PI LADIGES, WARREN C · 2014 to 2016
$1.1M
NIA NIH HHS P30 AG013319NIA NIH HHS P30 AG044271NIA NIH HHS R24 AG047115NIA NIH HHS R24 AG047115-01
6 · The paper itself

Abstract

Geropathology is the study of aging and age-related lesions and diseases in the form of whole necropsies/autopsies, surgical biopsies, histology, and molecular biomarkers. It encompasses multiple subspecialties of geriatrics, anatomic pathology, molecular pathology, clinical pathology, and gerontology. In order to increase the consistency and scope of communication in the histologic and molecular pathology assessment of tissues from preclinical and clinical aging studies, a Geropathology Research Network has been established consisting of pathologists and scientists with expertise in the comparative pathology of aging, the design of aging research studies, biostatistical methods for analysis of aging data, and bioinformatics for compiling and annotating large sets of data generated from aging studies. The network provides an environment to promote learning and exchange of scientific information and ideas for the aging research community through a series of symposia, the development of uniform ways of integrating pathology into aging studies, and the statistical analysis of pathology data. The efforts of the network are ultimately expected to lead to a refined set of sentinel biomarkers of molecular and anatomic pathology that could be incorporated into preclinical and clinical aging intervention studies to increase the relevance and productivity of these types of investigations.

Indexed as

Biomedical ResearchOrganizational ObjectivesAgedAgingAnimalsComputational BiologyCongresses as TopicGeriatricsHumansPathologyStatistics as TopicAgingGeropathologyGeropathology Research NetworkHealth span.Healthy agingHistopathologyLife-spanMolecular pathology

Identifiers

PMID26243216
PMCPMC5014185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.