ArticlePhysiological reports2015
Heat stress increases insulin sensitivity in pigs.
Article in Physiological reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 55 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
55 citing papers in PubMed, 2 syntheses or guidelines pooled it, 120 citations in OpenAlex.
- Systematic review of animal-based indicators to measure thermal, social, and immune-related stress in pigs.PloS one · 2022Pooled it
- Impacts on performance of growing-finishing pigs under heat stress conditions: a meta-analysis.Veterinary research communications · 2019Pooled it
- Early-Life Swine Inflammation and Necrosis Syndrome Is Associated with Later Tail Integrity and Systemic Hematological Changes in Organically Raised Pigs.Animals : an open access journal from MDPI · 2026Article
- From Systemic Stress to Ovarian Failure: Heat Stress-Induced Infertility in Pigs as a Model for Reproductive Dysfunction.Current issues in molecular biology · 2026Review
- Effects of a Dietary Blend of Essential Oils, Capsaicin, and Yeast Metabolites on Performance, Physiological, Metabolism, and Immune Response of Heat-Stressed Pigs.Veterinary sciences · 2025Article
- Breed- and Line-Dependent Severity of Inflammation and Necrosis Syndrome in AI Boars, and the Related Risk of Inflammation and Necrosis in Their Progeny.Veterinary sciences · 2025Article
- Heat Stress and Betaine Affect Lipolysis in Pig Adipose Tissue Explants.Animals : an open access journal from MDPI · 2025Article
- Article
- Inflammation and Necrosis Syndrome in Young Piglets-A Longitudinal Study.Veterinary sciences · 2025Article
- Screening of Piglets for Signs of Inflammation and Necrosis as Early Life Indicators of Animal Health and Welfare Hazards.Animals : an open access journal from MDPI · 2025Article
- Prolactin and heat stress; focus on domestic ruminants.Journal of animal science · 2025Review
- Climate-smart livestock nutrition in semi-arid Southern African agricultural systems.Frontiers in veterinary science · 2025Review
- IMPACT OF REAL-LIFE ENVIRONMENTAL EXPOSURES ON REPRODUCTION: Systemic and ovarian impacts of heat stress in the porcine model.Reproduction (Cambridge, England) · 2024Review
- A Capsaicin-Based Phytogenic Solution Improves Performance and Thermal Tolerance of Heat-Stressed Growing Pigs.Animals : an open access journal from MDPI · 2024Article
- Multi-tissue metabolic and transcriptomic responses to a short-term heat stress in swine.BMC genomics · 2024Article
- Therapeutic effects of mitoquinol during an acute heat stress challenge in growing barrows.Journal of animal science · 2024Article
- Effects of supplemental citrulline on thermal and intestinal morphology parameters during heat stress and feed restriction in growing pigs.Journal of animal science · 2024Article
- Heat stress alters hematological parameters in barrows and gilts.Journal of animal science · 2024Article
- Glucose Supplementation Improves Performance and Alters Glucose Transporters' Expression inAnimals : an open access journal from MDPI · 2023Article
- Reducing Stocking Densities and Using Cooling Systems for More Adapted Pigs to High Temperatures When Reared in Intensive Conditions.Animals : an open access journal from MDPI · 2023Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proper insulin homeostasis appears critical for adapting to and surviving a heat load. Further, heat stress (HS) induces phenotypic changes in livestock that suggest an increase in insulin action. The current study objective was to evaluate the effects of HS on whole-body insulin sensitivity. Female pigs (57 ± 4 kg body weight) were subjected to two experimental periods. During period 1, all pigs remained in thermoneutral conditions (TN; 21°C) and were fed ad libitum. During period 2, pigs were exposed to: (i) constant HS conditions (32°C) and fed ad libitum (n = 6), or (ii) TN conditions and pair-fed (PFTN; n = 6) to eliminate the confounding effects of dissimilar feed intake. A hyperinsulinemic euglycemic clamp (HEC) was conducted on d3 of both periods; and skeletal muscle and adipose tissue biopsies were collected prior to and after an insulin tolerance test (ITT) on d5 of period 2. During the HEC, insulin infusion increased circulating insulin and decreased plasma C-peptide and nonesterified fatty acids, similarly between treatments. From period 1 to 2, the rate of glucose infusion in response to the HEC remained similar in HS pigs while it decreased (36%) in PFTN controls. Prior to the ITT, HS increased (41%) skeletal muscle insulin receptor substrate-1 protein abundance, but did not affect protein kinase B or their phosphorylated forms. In adipose tissue, HS did not alter any of the basal or stimulated measured insulin signaling markers. In summary, HS increases whole-body insulin-stimulated glucose uptake.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.