ArticleJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology2016
The effects of 18-h fasting with low-carbohydrate diet preparation on suppressed physiological myocardial (18)F-fluorodeoxyglucose (FDG) uptake and possible minimal effects of unfractionated heparin use in patients with suspected cardiac involvement sarcoidosis.
Article in Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 75 papers, 1 of them a synthesis that pooled it.
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75 citing papers in PubMed, 1 synthesis or guideline pooled it, 163 citations in OpenAlex.
- Meta-analysis of the effectiveness of heparin in suppressing physiological myocardial FDG uptake in PET/CT.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Pooled it
- 18F-fluorodeoxyglucose use after cardiac transplant: A comparative study of suppression of physiological myocardial uptake.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2020Trial
- Effect of long fasting on myocardial accumulation in 18F-fluorodeoxyglucose positron emission tomography after chemoradiotherapy for esophageal carcinoma.Journal of radiation research · 2018Trial
- Interpretation of myocardial FDG uptake during corticosteroid therapy in cardiac sarcoidosis evaluation withAnnals of nuclear medicine · 2026Article
- Strict carbohydrate restriction enables volume-based FDG-PET/CT to outperform SUVmax for risk stratification in cardiac sarcoidosis.International journal of cardiology. Heart & vasculature · 2026Article
- Determinants of diagnostic yield and scan quality of [Critical care (London, England) · 2026Article
- Optimizing PET/CT protocols: is 60-minute [18 F]F-FDG uptake sufficient for cardiac sarcoidosis?EJNMMI research · 2026Article
- Review
- Cardiovascular imaging in cardio-oncology.Japanese journal of radiology · 2024Review
- Can FDG PET Serve as a Clinically Relevant Tool for Detecting Active Non-sarcoidotic Myocarditis?Nuclear medicine and molecular imaging · 2024Review
- How to prepare a patient for 18F-fluorodeoxyglucose positron emission tomography imaging to assess myocardial inflammation.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2024Article
- Physiological myocardialAsia Oceania journal of nuclear medicine & biology · 2024Article
- Current status and perspectives of nuclear cardiology.Annals of nuclear medicine · 2024Review
- Cardiovascular magnetic resonance (CMR) and positron emission tomography (PET) imaging in the diagnosis and follow-up of patients with acute myocarditis and chronic inflammatory cardiomyopathy : A review paper with practical recommendations on behalf of the European Society of Cardiovascular Radiology (ESCR).The international journal of cardiovascular imaging · 2023Review
- Diagnostic values of delayed additional FDG PET/CT scan in the evaluation of cardiac sarcoidosis.Annals of nuclear medicine · 2023Article
- Methotrexate for cardiac sarcoidosis: is it justifiable?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Hot spot imaging in cardiovascular diseases: an information statement from SNMMI, ASNC, and EANM.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Effective suppression of myocardial glucose uptake using predesigned low-carbohydrate boxed meals.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Article
- Hybrid imaging of neuroendocrine tumors in the heart: Union is strength.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2023Review
- [Hybrid PET/MRI for inflammatory cardiomyopathy].Radiologie (Heidelberg, Germany) · 2022Review
15 more citing papers are in PubMed but not listed here.
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11 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
background(18)F-fluorodeoxyglucose (FDG) PET plays an important role in the detection of cardiac involvement sarcoidosis (CS). However, diffuse left ventricle (LV) wall uptake sometimes makes it difficult to distinguish between positive uptake and physiological uptake. The aims of this study were to evaluate the effects of 18-h fasting with low-carbohydrate diet (LCD) vs a minimum of 6-h fasting preparations on diffuse LV FDG uptake and free fatty acid (FFA) levels in patients with suspected CS.
methodsEighty-two patients with suspected CS were divided into 2 preparation protocols: one with a minimum 6-h fast without LCD preparation (group A, n = 58) and the other with a minimum 18-h fast with LCD preparation (group B, n = 24). All patients also received intravenous unfractionated heparin (UFH; 50 IU/kg) before the injection of FDG.
resultsGroup A showed a higher percentage of diffuse LV uptake than did group B (27.6 vs 0.0%, P = .0041). Group B showed higher FFA levels (1159.1 ± 393.0, 650.5 ± 310.9 μEq/L, P < .0001) than did group A. Patients with diffuse LV uptake (n = 16) showed lower FFA levels than did other patients (n = 66) (432.1 ± 296.1, 888.4 ± 381.4 μEq/L, P < .0001). UFH administration significantly increased FFAs in both groups, even in the patients with diffuse LV FDG uptake.
conclusionsThe 18-h fast with LCD preparation significantly reduced diffuse LV uptake and increased FFA levels. In particular, the FFA level was significantly lower in patients with LV diffuse uptake than in patients without LV diffuse uptake. Acutely increasing plasma FFA through the use of UFH may not have a significant role in reducing physiological LV FDG uptake.
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