ArticleClinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology2016
An improved electrical impedance myography (EIM) tongue array for use in clinical trials.
Article in Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Trial
- Electrical impedance phase variation in relation to articulation manner.Scientific reports · 2025Article
- Surface electrical impedance myography detects disease in an adult-onset SOD1-G93A zebrafish model of amyotrophic lateral sclerosis.Scientific reports · 2025Article
- Localized Bioimpedance Measurements with the MAX3000x Integrated Circuit: Characterization and Demonstration.Sensors (Basel, Switzerland) · 2021Article
- In vivo muscle conduction study of the tongue using a multi-electrode tongue depressor.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- Flexible PCB Failures From Dynamic Activity and Their Impacts on Bioimpedance Measurements: A Wearable Case Study.IEEE open journal of circuits and systems · 2021Article
- A Bioimpedance-Based Device to Assess the Volume Conduction Properties of the Tongue in Neurological Disorders Affecting Bulbar function.IEEE open journal of engineering in medicine and biology · 2021Article
- Electrical Impedance Methods in Neuromuscular Assessment: An Overview.Cold Spring Harbor perspectives in medicine · 2019Review
- Electrical Impedance Myography and Its Applications in Neuromuscular Disorders.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Review
- Tongue electrical impedance in amyotrophic lateral sclerosis modeled using the finite element method.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesElectrical impedance myography (EIM) measurements of the tongue could provide valuable information about bulbar dysfunction in amyotrophic lateral sclerosis (ALS). A prototype tongue depressor EIM array produced gag reflexes. The objectives of this study were to determine the reliability, mean phase values, and tolerability of tongue EIM measurements using a smaller electrode array.
methodsTongue EIM measurements were performed in a total of 31 healthy individuals and four neuromuscular patients with lingual abnormalities. Reliability was assessed by calculating the intraclass correlation coefficient (ICC) and percent difference in addition to performing Bland-Altman analyses. Standard descriptive statistics, including results of a Mann-Whitney test, were also determined.
resultsAt the 50 kHz frequency, the ICCs for intra- and inter-rater reliability were 0.76 with 5.17% difference and 0.78 with 5.34% difference respectively. The mean EIM phase values of healthy participants (11.61° ± 1.00°) and patients (9.87° ± 1.28°) were significantly different (p=0.0051). None of the participants experienced gag reflexes or discomfort.
conclusionsThe small tongue array provided good inter- and intra-rater reliability, could preliminarily distinguish between healthy and diseased muscle, and was well-tolerated. SIGNIFICANCE: Biomarker information about tongue health could be more comfortably obtained with a smaller EIM array.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.