Evidence map›Paper›PMID 26242746›Full record

ArticleNature communications2015

CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury.

Hirokuni Akahori, Vinit Karmali, Rohini Polavarapu, Alicia N Lyle, Daiana Weiss, Eric Shin, Ahsan Husain, Nawazish Naqvi, Richard Van Dam, Anwer Habib and 6 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 57 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Hirokuni AkahoriDepartment of Internal Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA.
Vinit KarmaliDepartment of Internal Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA.
Rohini PolavarapuDepartment of Internal Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA.
Alicia N LyleDepartment of Internal Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA.
Daiana WeissDepartment of Internal Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA.
Eric ShinDepartment of Internal Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA.
Ahsan HusainDepartment of Internal Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA.
Nawazish NaqviDepartment of Internal Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA.
Richard Van DamDepartment of Internal Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA.
Anwer HabibDepartment of Internal Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA.
Cheol Ung Choi1] Department of Internal Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA [2] Division of Cardiology, Cardiovascular Center, Korea University Guro Hospital, Korea University College of Medicine, Seoul 152-703, Republic of Korea.
Adrienne L KingKennesaw State University Department of Ecology, Evolution, and Organismal Biology Kennesaw, Georgia 30144, USA.
Kimberly PachuraDepartment of Internal Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA.
W Robert Taylor1] Department of Internal Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA [2] Atlanta VA Medical Center, Atlanta, Georgia 30033, USA [3] Coulter Department of Biomedical Engineering at Georgia Tech and Emory, Atlanta, Georgia 30332, USA.
David J LeferLSU Health Sciences Center, New Orleans, Louisiana 70112, USA.
Aloke V FinnDepartment of Internal Medicine, Division of Cardiology, Emory University, Atlanta, Georgia 30322, USA.
Emory University · USKennesaw State University · USKorea University Medical Center · KRLouisiana State University Health Sciences Center New Orleans · US

Funding

Functional Cardio-MetabolomicsP20HL113452 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI HAZEN, STANLEY L, TANG, WAI HONG WILSON · 2012 to 2016
$4.8M
6 · The paper itself

Abstract

Macrophages are an essential component of the immune response to ischaemic injury and play an important role in promoting inflammation and its resolution, which is necessary for tissue repair. The type I transmembrane glycoprotein CD163 is exclusively expressed on macrophages, where it acts as a receptor for haemoglobin:haptoglobin complexes. An extracellular portion of CD163 circulates in the blood as a soluble protein, for which no physiological function has so far been described. Here we show that during ischaemia, soluble CD163 functions as a decoy receptor for TWEAK, a secreted pro-inflammatory cytokine of the tumour necrosis factor family, to regulate TWEAK-induced activation of canonical nuclear factor-κB (NF-κB) and Notch signalling necessary for myogenic progenitor cell proliferation. Mice with deletion of CD163 have transiently elevated levels of TWEAK, which stimulate muscle satellite cell proliferation and tissue regeneration in their ischaemic and non-ischaemic limbs. These results reveal a role for soluble CD163 in regulating muscle regeneration after ischaemic injury.

Indexed as

RegenerationAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenCytokine TWEAKMacrophagesMaleMice, KnockoutMuscle, SkeletalNF-kappa BRandom AllocationReceptors, Cell SurfaceReceptors, NotchReperfusion InjuryTumor Necrosis FactorsAntigens, CDAntigens, Differentiation, MyelomonocyticCD163 AntigenCytokine TWEAKNF-kappa BReceptors, Cell SurfaceReceptors, NotchTnfsf12 protein, mouseTumor Necrosis Factors

Identifiers

PMID26242746
PMCPMC4918310
OpenAlexW1133776218

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.