Evidence map›Paper›PMID 26242480›Full record

ArticleMolecular imaging and biology2016

Predicting Response to Therapy for Autoimmune and Inflammatory Diseases Using a Folate Receptor-Targeted Near-Infrared Fluorescent Imaging Agent.

Lindsay E Kelderhouse, Sakkarapalayam Mahalingam, Philip S Low

Abstract read
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In one paragraph

Article in Molecular imaging and biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
3.0field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

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  14. Nanomedicines for dysfunctional macrophage-associated diseases.Journal of controlled release : official journal of the Controlled Release Society · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lindsay E KelderhouseDepartment of Chemistry, Purdue University, 720 Clinic Drive, West Lafayette, IN, 47907, USA.
Sakkarapalayam MahalingamDepartment of Chemistry, Purdue University, 720 Clinic Drive, West Lafayette, IN, 47907, USA.
Philip S LowDepartment of Chemistry, Purdue University, 720 Clinic Drive, West Lafayette, IN, 47907, USA. plow@purdue.edu.
Purdue University West Lafayette · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeAlthough current therapies for many inflammatory/autoimmune diseases are effective, a significant number of patients still exhibit only partial or negligible responses to therapeutic intervention. Since prolonged use of an inadequate therapy can result in both progressive tissue damage and unnecessary expense, methods to identify nonresponding patients are necessary. PROCEDURES: Four murine models of inflammatory disease (rheumatoid arthritis, ulcerative colitis, pulmonary fibrosis, and atherosclerosis) were induced, treated with anti-inflammatory agents, and evaluated for inflammatory response. The mice were also injected intraperitoneally with OTL0038, a folate receptor-targeted near-infrared dye that accumulates in activated macrophages at sites of inflammation. Uptake of OTL0038 in inflamed lesions was then correlated with clinical measurements of disease severity.

resultsOTL0038 accumulated at sites of inflammation in all four animal models. More importantly, changes in lesion-associated OTL0038 preceded changes in clinical symptoms in mice treated with all anti-inflammatory drugs examined.

conclusionOTL0038 has the ability to predict responses to multiple therapies in four murine models of inflammation.

Indexed as

AnimalsArthritis, RheumatoidAtherosclerosisAutoimmune DiseasesCattleColitis, UlcerativeColonFemaleFluorescenceFolate Receptors, GPI-AnchoredInflammationMaleMice, Inbred BALB CMice, Inbred C57BLMolecular ImagingPulmonary FibrosisFolate Receptors, GPI-AnchoredActivated macrophagesAtherosclerosis imagingFluorescence imaging of autoimmune diseaseFolate receptor targetingIdiopathic pulmonary fibrosis imagingInflammatory and autoimmune diseasesNear-infrared fluorescent dyeRheumatoid arthritis imagingUlcerative colitis imaging

Identifiers

PMID26242480
OpenAlexW2266360899

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.