ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2016
Histological mixed-type as an independent risk factor for nodal metastasis in submucosal gastric cancer.
Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 3 of them syntheses that pooled it.
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17 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Pooled it
- Relationship between histological mixed-type early gastric cancer and lymph node metastasis: A systematic review and meta-analysis.PloS one · 2022Pooled it
- Endoscopic Submucosal Dissection of Early Gastric Cancer with Mixed-Type Histology: A Systematic Review.Digestive diseases and sciences · 2020Pooled it
- Clinicopathological features of endoscopically treated early gastric cancer with lymphovascular infiltration.Journal of cancer research and clinical oncology · 2023Article
- Endoscopic Resection of Undifferentiated Early Gastric Cancer.Journal of gastric cancer · 2023Review
- Prognostic value of molecular cytology by one-step nucleic acid amplification (OSNA) assay of peritoneal washings in advanced gastric cancer patients.Scientific reports · 2022Article
- Late recurrence of early gastric cancer 11 years after curative endoscopic submucosal dissection.International cancer conference journal · 2022Article
- Lymph node metastasis risk factors and applicability of endoscopic submucosal dissection in mixed-type early gastric cancer in Chinese patients.Journal of gastrointestinal oncology · 2021Article
- Article
- Changing trends of clinicopathologic features and survival duration after surgery for gastric cancer in Northeast China.World journal of gastrointestinal oncology · 2020Article
- Histopathological validation of magnifying endoscopy for diagnosis of mixed-histological-type early gastric cancer.World journal of gastroenterology · 2020Article
- Predictive Factors for Lymph Node Metastasis and the Effect on Survival in Early Gastric Cancer Patients with Radical Gastric Resection.Sisli Etfal Hastanesi tip bulteni · 2019Article
- Consensus on the pathological definition and classification of poorly cohesive gastric carcinoma.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2019Article
- Differential analysis of lymph node metastasis in histological mixed-type early gastric carcinoma in the mucosa and submucosa.World journal of gastroenterology · 2018Article
- Risk factors for lymph node metastasis of early gastric cancers in patients younger than 40.Medicine · 2017Observational
- Early gastric cancer with a mixed-type Lauren classification is more aggressive and exhibits greater lymph node metastasis.Journal of gastroenterology · 2017Article
- Risk of lymph node metastasis in mixed-type early gastric cancer determined by the extent of the poorly differentiated component.World journal of gastroenterology · 2016Article
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Authors and funding
11 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent studies reported that the histological mixed-type, which consists of differentiated and undifferentiated components, was related to the aggressive clinical features of gastric cancer as well as its poor outcomes. This study was designed to investigate the influences of the mixed-type on lymph node metastasis in patients with submucosal gastric cancer. We analyzed a total of 239 consecutive patients who underwent curative gastrectomy for submucosal gastric cancer between 2004 and 2012 from their hospital records. The overall prevalence of histological mixed-type in submucosal gastric cancer was 46.9 % (112/239). The histological mixed-type correlated more strongly with lymph node metastasis (P = 0.0016; 25.0 % (28/112)) than the undifferentiated type in the Japanese classification of gastric carcinoma (JCGC) (P = 0.2779; 20.5 % (17/83)) and 7th tumor-node-metastasis (TNM) (P = 0.0476; 20.7 % (31/150)) classifications. Univariate and multivariate logistic regression analyses identified a tumor size of 25 mm or greater (P = 0.0003, OR 4.51 (95 % CI 1.95-11.9)) and the histological mixed-type (P = 0.0316, OR 4.02 (95 % CI 1.12-19.2)) as independent risk factors for lymph node metastasis. The incidence of lymph node metastasis was high in patients with both these factors (33.8 % (23/68)) and low in patients without both factors (3.0 % (2/67)). These results suggest that the histological mixed-type correlated more strongly with lymph node metastasis than the undifferentiated type in the JCGC and TNM classifications and highlight its usefulness as a risk factor for lymph node metastasis in submucosal gastric cancer.
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