ArticleReproductive biology and endocrinology : RB&E2015
A transcriptomal analysis of bovine oviductal epithelial cells collected during the follicular phase versus the luteal phase of the estrous cycle.
Article in Reproductive biology and endocrinology : RB&E, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 69 citations in OpenAlex.
- Hormonally responsive bovine oviductal organoids recapitulate native oviductal secretions and enhance sperm capacitation.Cellular and molecular life sciences : CMLS · 2026Article
- Characterization of bovine oviductal organoids: Polarity, cryopreservation, hormonal stimulation, and extracellular vesicles.Cell and tissue research · 2026Article
- Organoids simulating the bovine oviduct mediate the embryo-maternal interface via extracellular vesicle-transmitted signaling.Human reproduction open · 2026Article
- Three-Dimensional Magnetic Bioprinting Spheroids as an In Vitro Model to Study the Oviductal Physiology.Molecular reproduction and development · 2025Article
- Unveiling the role of protein kinase A (PKA) activity in bovine oviductal epithelial cells: implications on apoptotic signaling pathways during the estrous cycle.Cell and tissue research · 2024Article
- Identification and characterization of calcium binding protein, spermatid-associated 1 (CABS1)# in selected human tissues and fluids.PloS one · 2024Article
- Neurotensin and Its Involvement in Reproductive Functions: An Exhaustive Review of the Literature.International journal of molecular sciences · 2023Review
- Oviduct Transcriptomic Reveals the Regulation of mRNAs and lncRNAs Related to Goat Prolificacy in the Luteal Phase.Animals : an open access journal from MDPI · 2022Article
- Clinical, laboratory, and morphological diagnosis of diseases in the oviducts and paraovarian structures of cows.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2022Article
- Effect of estrous cycle phases on gene expression in bovine oviduct epithelial cells.Veterinary world · 2022Article
- Article
- Spatiotemporal profiling of the bovine oviduct fluid proteome around the time of ovulation.Scientific reports · 2022Article
- Neurotransmitters, neuropeptides and calcium in oocyte maturation and early development.Frontiers in cell and developmental biology · 2022Review
- Spatiotemporal transcriptional dynamics of the cycling mouse oviduct.Developmental biology · 2021Article
- Neurotensin: A novel mediator of ovulation?FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Expression Profiles of the Progesterone Receptor, Cyclooxygenase-2, Growth Differentiation Factor 9, and Bone Morphogenetic Protein 15 Transcripts in the Canine Oviducts during the Oestrous Cycle.Animals : an open access journal from MDPI · 2021Article
- Steroidal Regulation of Oviductal microRNAs Is Associated with microRNA-Processing in Beef Cows.International journal of molecular sciences · 2021Article
- Exosomes as a Potential Tool for Supporting Canine Oocyte Development.Animals : an open access journal from MDPI · 2020Review
- Effect of neurotensin on cultured mouse preimplantation embryos.The Journal of reproduction and development · 2020Article
- Neurotensin stimulates the sperm acrosome reaction and reduces percentages of fertilization in vitro.F&S science · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundReproductive success depends on a functional oviduct for gamete storage, maturation, fertilization, and early embryonic development. The ovarian-derived steroids estrogen and progesterone are key regulators of oviductal function. The objective of this study was to investigate luteal and follicular phase-specific oviductal epithelial cell function by using microarray-based transcriptional profiling, to increase our understanding of mRNAs regulating epithelial cell processes, and to identify novel genes and biochemical pathways that may be found to affect fertility in the future.
methodsSix normally cycling Angus heifers were assigned to either luteal phase (LP, n = 3) or follicular phase (FP, n = 3) treatment groups. Heifers in the LP group were killed between day 11 and 12 after estrus. Heifers in the FP group were treated with 25 mg PGF2α (Lutalyse, Pfizer, NY) at 8 pm on day 6 after estrus and killed 36 h later. Transcriptional profiling by microarray and confirmation of selected mRNAs by real-time RT-PCR analyses was performed using total RNA from epithelial cells isolated from sections of the ampulla and isthmus collected from LP and FP treatment groups. Differentially expressed genes were subjected to gene ontology classification and bioinformatic pathway analyses.
resultsStatistical one-way ANOVA using Benjamini-hochberg multiple testing correction for false discovery rate (FDR) and pairwise comparison of epithelial cells in the ampulla of FP versus LP groups revealed 972 and 597 transcripts up- and down-regulated, respectively (P < 0.05). Within epithelial cells of the isthmus in FP versus LP groups, 946 and 817 transcripts were up- and down-regulated, respectively (P < 0.05). Up-regulated genes from both ampulla and isthmus were found to be largely involved in cholesterol biosynthesis and cell cycle pathways, while down-regulated genes were found in numerous inflammatory response pathways.
conclusionsMicroarray-based transcriptional profiling revealed phase of the cycle-dependent changes in the expression of mRNA within the epithelium of the oviducts' ampulla and isthmus.
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Registered trials
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