ReviewBMC infectious diseases2015
Trichomonas vaginalis: a review of epidemiologic, clinical and treatment issues.
Review in BMC infectious diseases, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01832480 (Trichomonas Vaginalis Repeat Infections Among HIV Negative Women), which is not on this map. Cited by 160 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trichomonas Vaginalis Repeat Infections Among HIV Negative Women
Who cites it
160 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The prevalence of Trichomonas vaginalis infection among the female population of Iran: a systematic review and meta-analysis.International health · 2024Pooled it
- Global prevalence of Trichomonas vaginalis among female sex workers: a systematic review and meta-analysis.Parasitology research · 2021Pooled it
- Single-dose versus 7-day-dose metronidazole for the treatment of trichomoniasis in women: an open-label, randomised controlled trial.The Lancet. Infectious diseases · 2018Trial
- Comparative Performance of Aptima BV/CV-TV and Vaginal Real Time Assays for the Molecular Diagnosis of Bacterial Vaginosis and Vaginitis.Diagnostics (Basel, Switzerland) · 2026Article
- Machine Learning Classification Models for the Design of Novel Nitroimidazole Derivatives with Anti-ACS omega · 2026Article
- Novel Multiplex Near-Point-of-Care PCR Assay for Detecting Sexually Transmitted Infections Among PrEP Users in Western Kenya: Protocol for a Cross-Sectional Pilot Study With an Epidemiological Assessment.JMIR research protocols · 2026Article
- Transcriptomic Signatures ofMicroorganisms · 2026Article
- Genital inflammation screening for predicting sexually transmitted infections and bacterial vaginosis: an updated cost analysis from the GIFT study in Madagascar, South Africa, and Zimbabwe.BMC women's health · 2026Observational
- A repeated cross-sectional analysis of routine leucorrhea test results in women from Jianyang City, Western China (2022-2024) and exploration of the significance of health screening.BMC women's health · 2026Article
- Antimicrobial Activity of D-Form Synthetic Peptides Against Metronidazole-Resistant and SusceptibleInternational journal of molecular sciences · 2026Article
- Evaluation of Alinity m STI Assay for Simultaneous Detection of Chlamydia trachomatis , Neisseria gonorrhoeae , Trichomonas vaginalis , and Mycoplasma genitalium in Female Urogenital Specimens.Sexually transmitted diseases · 2026Article
- Global burden of disease and future trends of trichomoniasis in women of reproductive age from 1990 to 2021.Journal of health, population, and nutrition · 2026Article
- Immunomodulatory Effects of the Antimicrobial Peptide KR-20: Implications for Trichomoniasis.Molecules (Basel, Switzerland) · 2026Article
- Influence of DNA methylation and chromatin accessibility on regulation of gene expression duringmBio · 2026Article
- IKK2, calcium, MAP kinase, and PI3 kinase are required for exocytosis and interleukin-8 production in human mast cells stimulated by Trichomonas vaginalis-derived secretory products.Parasites, hosts and diseases · 2026Article
- Sexually Transmitted Infections in adolescents and young adults: a growing public health challenge.Le infezioni in medicina · 2026Review
- Trichomonas vaginalis strain diversity among female sex workers in Ecuador using DNA sequence-based typing.BMC infectious diseases · 2025Article
- Chromatin accessibility and gene expression in the parasite Trichomonas vaginalis.BMC infectious diseases · 2025Article
- Through thick and thin: The vaginal microbiome as both occupant and healer.PLoS pathogens · 2025Article
- Transmission Dynamics ofMicroorganisms · 2025Article
100 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
Trichomonas vaginalis (TV) is likely the most common non-viral sexually transmitted infection (STI) in the world. It is as an important source of reproductive morbidity, a facilitator of HIV transmission and acquisition, and thus it is an important public health problem. Despite its importance in human reproductive health and HIV transmission, it is not a reportable disease and surveillance is not generally done. This is problematic since most persons infected with TV are asymptomatic. Metronidazole (MTZ) has been the treatment of choice for women for decades, and single dose has been considered the first line of therapy. However, high rates of retest positive are found among TV infected persons after single dose MTZ treatment. This has not been explained by drug resistance since in vitro resistance is only 2-5 %. Treatment failure can range from 7-10 % and even higher among HIV+ women. Treatment efficacy may be influenced by vaginal ecology. The origins of repeat positives need further explanation and better treatment options are needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.