ArticlePloS one2015
Genome-Wide Analysis of Hypoxia-Responsive Genes in the Rice Blast Fungus, Magnaporthe oryzae.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 26 citations in OpenAlex.
- Transcriptomic Insights into Sre1-Related Regulatory Responses to Hypoxia, Cobalt Chloride, and Clotrimazole inJournal of fungi (Basel, Switzerland) · 2026Article
- Sterol Regulatory Element-Binding Protein Sre1 Mediates the Development and Pathogenicity of the Grey Mould FungusInternational journal of molecular sciences · 2025Article
- From Natural Hosts to Agricultural Threats: The Evolutionary Journey of Phytopathogenic Fungi.Journal of fungi (Basel, Switzerland) · 2025Review
- Article
- New Insights into the Connections between Flooding/Hypoxia Response and Plant Defenses against Pathogens.Plants (Basel, Switzerland) · 2024Review
- Transcriptome Analysis Reveals Potential Regulators of DMI Fungicide Resistance in the Citrus Postharvest PathogenJournal of fungi (Basel, Switzerland) · 2024Article
- Coordinated Regulation of Membrane Homeostasis and Drug Accumulation by Novel Kinase STK-17 in Response to Antifungal Azole Treatment.Microbiology spectrum · 2022Article
- Novel factors contributing to fungal pathogenicity at early stages of Setosphaeria turcica infection.Molecular plant pathology · 2022Article
- Morphological and transcriptomic analysis of attenuated and virulent strains of Phytophthora infestans.International microbiology : the official journal of the Spanish Society for Microbiology · 2022Article
- The Bicarbonate Transporter (MoAE4) Localized on Both Cytomembrane and Tonoplast Promotes Pathogenesis inJournal of fungi (Basel, Switzerland) · 2021Article
- Comparative Transcriptome and Endophytic Bacterial Community Analysis ofFrontiers in microbiology · 2021Article
- Hypoxia: A Double-Edged Sword During Fungal Pathogenesis?Frontiers in microbiology · 2020Review
- Host-Induced Gene Silencing ofFrontiers in plant science · 2019Article
- Multi-omics integrative analysis with genome-scale metabolic model simulation reveals global cellular adaptation of Aspergillus niger under industrial enzyme production condition.Scientific reports · 2018Article
- SUMOylation is required for fungal development and pathogenicity in the rice blast fungus Magnaporthe oryzae.Molecular plant pathology · 2018Article
- Phosphorylation-mediated Regulatory Networks in Mycelia ofMolecular & cellular proteomics : MCP · 2017Article
- Using Network Extracted Ontologies to Identify Novel Genes with Roles in Appressorium Development in the Rice Blast Fungus Magnaporthe oryzae.Microorganisms · 2017Article
- Functional analysis of two sterol regulatory element binding proteins in Penicillium digitatum.PloS one · 2017Article
- Transcriptomic Crosstalk between Fungal Invasive Pathogens and Their Host Cells: Opportunities and Challenges for Next-Generation Sequencing Methods.Journal of fungi (Basel, Switzerland) · 2016Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Rice blast fungus, Magnaporthe oryzae, is the most destructive pathogen in the rice-growing area. This fungus has a biotrophic phase early in infection and later switches to a necrotrophic lifestyle. During the biotrophic phase, the fungus competes with its host for nutrients and oxygen. Continuous uptake of oxygen is essential for successful establishment of blast disease of this pathogen. Here, we report transcriptional responses of the fungus to oxygen limitation. Transcriptome analysis using RNA-Seq identified that 1,047 genes were up-regulated in response to hypoxia. Those genes are involved in mycelial development, sterol biosynthesis, and metal ion transport based on hierarchical GO terms, and are well-conserved among three fungal species. In addition, null mutants of two hypoxia-responsive genes were generated and their roles in fungal development and pathogenicity tested. The mutant for the sterol regulatory element-binding protein gene, MoSRE1, exhibited increased sensitivity to a hypoxia-mimicking agent, increased conidiation, and delayed invasive growth within host cells, which is suggestive of important roles in fungal development. However, such defects did not cause any significant decrease in disease severity. The other null mutant, for the alcohol dehydrogenase gene MoADH1, showed no defect in the hypoxia-mimicking condition (using cobalt chloride) and fungal development. Taken together, this comprehensive transcriptional profiling in response to a hypoxic condition with experimental validations would provide new insights into fungal development and pathogenicity in plant pathogenic fungi.
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