ArticlePloS one2015
Bacillus cereus ATCC 14579 RpoN (Sigma 54) Is a Pleiotropic Regulator of Growth, Carbohydrate Metabolism, Motility, Biofilm Formation and Toxin Production.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Unveiling the Functions of Two RpoNs inInternational journal of molecular sciences · 2026Article
- Development of phage-resistantFood chemistry: X · 2026Article
- Transcriptomic response of Xanthomonas campestris during xanthan gum production to glutamate concentration.Scientific reports · 2026Article
- The major toxins of Bacillus cereus - Current knowledge on distribution, regulation and mechanism of action.EXCLI journal · 2026Review
- Sigma B regulated motility and chemotaxis inMicrobiology (Reading, England) · 2026Article
- RpoN mediates biofilm formation by directly controllingBiofilm · 2025Article
- ProPr54 web server: predicting σNAR genomics and bioinformatics · 2025Article
- Analysis and comparison of the bacterial σ54 regulon: Evidence of phylogenetic trends in gene regulation.PloS one · 2025Article
- Impact of Graphene Layers on Genetic Expression and Regulation within Sulfate-Reducing Biofilms.Microorganisms · 2024Article
- Evaluating the Safety ofMicroorganisms · 2024Article
- Molecular mechanism of the one-component regulator RccR on bacterial metabolism and virulence.Nucleic acids research · 2024Article
- An Investigation of Quorum Sensing Inhibitors againstMarine drugs · 2024Article
- Transcriptome profiling of type VI secretion system core geneMicrobiology spectrum · 2024Article
- Exploring the cellular surface polysaccharide and root nodule symbiosis characteristics of theMicrobiology spectrum · 2023Article
- Transcriptome Analysis of Protocatechualdehyde againstFoods (Basel, Switzerland) · 2023Article
- Insight into the Cold Adaptation Mechanism of an Aerobic Denitrifying Bacterium: Bacillus simplex H-b.Applied and environmental microbiology · 2023Article
- SigB modulates expression of novel SigB regulon members via Bc1009 in non-stressed and heat-stressed cells revealing its alternative roles in Bacillus cereus.BMC microbiology · 2023Article
- The Alternative Sigma Factor SigL InfluencesFrontiers in microbiology · 2022Article
- Article
- Phenotypic and genomic characterization of aMicrobial genomics · 2021Article
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sigma 54 is a transcriptional regulator predicted to play a role in physical interaction of bacteria with their environment, including virulence and biofilm formation. In order to study the role of Sigma 54 in Bacillus cereus, a comparative transcriptome and phenotypic study was performed using B. cereus ATCC 14579 WT, a markerless rpoN deletion mutant, and its complemented strain. The mutant was impaired in many different cellular functions including low temperature and anaerobic growth, carbohydrate metabolism, sporulation and toxin production. Additionally, the mutant showed lack of motility and biofilm formation at air-liquid interphase, and this correlated with absence of flagella, as flagella staining showed only WT and complemented strain to be highly flagellated. Comparative transcriptome analysis of cells harvested at selected time points during growth in aerated and static conditions in BHI revealed large differences in gene expression associated with loss of phenotypes, including significant down regulation of genes in the mutant encoding enzymes involved in degradation of branched chain amino acids, carbohydrate transport and metabolism, flagella synthesis and virulence factors. Our study provides evidence for a pleiotropic role of Sigma 54 in B. cereus supporting its adaptive response and survival in a range of conditions and environments.
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