Evidence map›Paper›PMID 26241253›Full record

Trial reportObstetrics and gynecology2015

Ketorolac for Pain Control With Intrauterine Device Placement: A Randomized Controlled Trial.

Lynn L Ngo, Kristy K Ward, Sheila K Mody

5 registry-linked trialsOpen access · greenAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obstetrics and gynecology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 5 registered trials, which are not on this map. Cited by 13 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 2 pooled it
6.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01664559 nacompletednot on this map

Pain Control for Intrauterine Device Placement: A Randomized, Double Blind Control Trial of Ketorolac Prior to Intrauterine Device Placement.

TypeinterventionalSponsorLynn NgoRan2012 to 2014Enrolled67ConditionsPain Control With IUD InsertionArmsKetorolac, Normal Saline
NCT03868137 naunknown statusnot on this mapstarted 2020, after this paper: background citation

Multi-dose Ibuprofen Prophylaxis for IUD-insertion (MIPI): A Triple Blinded

TypeinterventionalSponsorOrlando VA Medical CenterRan2020 to 2022Enrolled86ConditionsPelvic Pain, IUDArmsIbuprofen, Placebos
NCT04963582 nacompletednot on this mapstarted 2021, after this paper: background citation

Does LI4 Acupuncture Provide an Effective Analgesia During Intrauterine Device

TypeinterventionalSponsorNigde Omer Halisdemir UniversityRan2021 to 2021Enrolled72ConditionsIUD Insertion Complication, Acute PainArmsAcupuncture
NCT05875571 phase4unknown statusnot on this mapstarted 2024, after this paper: background citation

Intravenous Ketorolac Administration to Attenuate Post-procedural Pain Associated With Intrauterine Device Placement: A Randomized, Double-Blind, Placebo-Controlled Trial

TypeinterventionalSponsorArkansas Children's Hospital Research InstituteRan2024 to 2025Enrolled18ConditionsIUD, Healthy Female, Contraception, IUD Insertion ComplicationArmsKetorolac, Placebo
NCT06853327 phase2enrolling by invitationnot on this mapstarted 2025, after this paper: background citation

Timing of Oral Ketorolac for Pain Reduction in IUD Insertion: A Double-Blind Randomized Controlled Trial

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2025 to 2026Enrolled108ConditionsIUD Insertion PainArmsKetorolac, Placebo
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 41 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Moving Past Anti-VEGF: Novel Therapies for Treating Diabetic Retinopathy.International journal of molecular sciences · 2016
    Review
  12. Continued Compliance and Degree of Satisfaction in Nulligravida and Parous Women with Intrauterine Contraceptive Devices.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2016
    Article
  13. New developments in intrauterine device use: focus on the US.Open access journal of contraception · 2016
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Lynn L NgoDepartment of Reproductive Medicine, University of California, San Diego, San Diego, California; and the Department of Obstetrics and Gynecology, University of Florida College of Medicine, Jacksonville, Florida.
Kristy K Ward
Sheila K Mody
University of California, San Diego · US

Funding

UC San Diego Womens Reproductive Health Research ProgramK12HD001259 · NICHD · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CYNTHIA GYAMFI-BANNERMAN · 1999 to 2026
$9.1M
NICHD NIH HHS K12 HD001259
6 · The paper itself

Abstract

objectiveTo evaluate intramuscular ketorolac compared with placebo saline injection for pain control with intrauterine device (IUD) placement.

methodsWe conducted a randomized, double-blind, placebo-controlled trial between July 2012 and March 2014. Patients received 30 mg ketorolac or placebo saline intramuscular injection 30 minutes before IUD placement. The primary outcome was pain with IUD placement on a 10-cm visual analog scale. Sample size was calculated to provide 80% power to show a 2.0-cm difference (α=0.05) in the primary outcome. Secondary outcomes included pain with study drug injection, speculum insertion, tenaculum placement, uterine sounding, and at 5 and 15 minutes after IUD placement.

resultsA total of 67 women participated in the study, 33 in the ketorolac arm and 34 in the placebo arm. There were no differences in baseline demographics including age, body mass index, and race. There were no differences in median pain scores for IUD placement in the placebo compared with ketorolac groups (5.2 compared with 3.6 cm, P=.99). There was a decrease in median pain scores at 5 minutes (2.2 compared with 0.3 cm, P≤.001) and 15 minutes (1.6 compared with 0.1 cm, P≤.001) after IUD placement but no difference for all other time points. Nulliparous participants (n=16, eight per arm) had a decrease in pain scores with IUD placement (8.1 compared with 5.4 cm, P=.02). In this study, 22% of participants in the placebo group and 18% in the ketorolac group reported injection pain was as painful as IUD placement.

conclusionKetorolac does not reduce pain with IUD placement but does reduce pain at 5 and 15 minutes after placement. CLINICAL

trial registrationClinicalTrials.gov; www.clinicaltrials.gov, NCT01664559. LEVEL OF EVIDENCE: I.

Indexed as

Intrauterine DevicesAdolescentAdultAnti-Inflammatory Agents, Non-SteroidalDouble-Blind MethodDrug Administration ScheduleFemaleHumansInjections, IntramuscularKetorolacMiddle AgedPainPain MeasurementPatient SatisfactionTreatment OutcomeYoung AdultAnti-Inflammatory Agents, Non-SteroidalKetorolac

Identifiers

PMID26241253
PMCPMC4527080
OpenAlexW2334837466

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.