Evidence map›Paper›PMID 26241139›Full record

ArticleCurrent biology : CB2015

Chromosome segregation: human female meiosis breaks all the rules.

Sarah E Zanders, Harmit S Malik

Open access · bronzeAbstract readComment
PubMed Publisher
In one paragraph

Article in Current biology : CB, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
4.0field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Mathematical modeling of human oocyte aneuploidy.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  7. Fertility Costs of Meiotic Drivers.Current biology : CB · 2019
    Review
  8. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 2 countries.

Sarah E ZandersDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Harmit S MalikDivision of Basic Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA; Howard Hughes Medical Institute, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA. Electronic address: hsmalik@fhcrc.org.
Cape Town HVTN Immunology Laboratory / Hutchinson Centre Research Institute of South Africa · ZAFred Hutch Cancer Center · US

Funding

Genetic Conflict Shapes Centromeres and HeterochromatinR01GM074108 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI MALIK, HARMIT S. · 2005 to 2022
$6.1M
Models of Selfishness: Molecular and Evolutionary Analyses of the Wtf Meiotic DriversDP2GM132936 · NIGMS · STOWERS INSTITUTE FOR MEDICAL RESEARCH · PI ZANDERS, SARAH ELIZABETH · 2018 to 2018
$2.5M
Mechanisms of meiotic drive and the functional consequences of rapid genome evolution in SchizosaccharomycesK99GM114436 · NIGMS · FRED HUTCHINSON CANCER RESEARCH CENTER · PI ZANDERS, SARAH ELIZABETH · 2015 to 2016
$112k
NIGMS NIH HHS DP2 GM132936NIGMS NIH HHS K99 GM114436NIGMS NIH HHS R01 GM074108
6 · The paper itself

Abstract

A major hindrance in studying human meiosis has been the inability to assess all four products of female meiosis. Overcoming this hurdle, a new study discovers a high incidence of non-canonical 'reverse meiosis' and a new form of meiotic drive.

Indexed as

Chromosome SegregationRecombination, GeneticFemaleHumans

Identifiers

PMID26241139
OpenAlexW1594364162

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.