ArticleEndocrinology2015
Life-Long Implications of Developmental Exposure to Environmental Stressors: New Perspectives.
Abstract readConference Proceedings
In one paragraph
Article in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 101 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
101citing papers in PubMed, 2 pooled it
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
101 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The influence of environmental exposures during the preconception period on offspring outcomes: a systematic review.Frontiers in public health · 2025Pooled it
- Health consequences of exposure to e-waste: an updated systematic review.The Lancet. Planetary health · 2021Pooled it
- Pediatric effects of forever chemicals may last for a long time.Pediatric research · 2026Review
- Association of DLK1-MEG3 methylation levels in cord blood with small for gestational age.Pediatric research · 2026Article
- A Call for Training Pediatric Practitioners About Industrial Chemicals and Child Health.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2026Article
- Health Risk and Pathogenesis of PMToxics · 2026Review
- The assumption of a threshold is false in risk assessments for endocrine disrupting chemicals (EDCs) when endogenous hormones being disrupted are already above any possible threshold: a policy failure by the US FDA.Environmental health : a global access science source · 2026Review
- Embryos are largely understudied in a representative sample of journals in conservation physiology.Conservation physiology · 2026Article
- Combined prenatal exposure to airborne polycyclic aromatic hydrocarbons and maternal distress is associated with childhood irritability.Frontiers in public health · 2026Article
- Early-Life Exposure to Organic Chemical Pollutants as Assessed in Primary Teeth and Cardiometabolic Risk in Mexican American Children: A Pilot Study.International journal of environmental research and public health · 2025Article
- PBDE Flame Retardant Exposure Causes Neurobehavioral and Transcriptional Effects in First-Generation but Not Second-Generation Offspring Fish.Environmental science & technology · 2025Article
- Prenatal black carbon exposure and DNA methylation in umbilical cord blood.International journal of hygiene and environmental health · 2025Article
- Prenatal exposure to Bisphenol-A as a risk factor for infant neurodevelopment.Frontiers in endocrinology · 2025Review
- Cross-cutting studies of per- and polyfluorinated alkyl substances (PFAS) in Arctic wildlife and humans.The Science of the total environment · 2024Review
- Sex-Specific Associations between Prenatal Exposure to Bisphenols and Phthalates and Infant Epigenetic Age Acceleration.Epigenomes · 2024Article
- Should Pregnant Women Consume Probiotics to Combat Endocrine-Disrupting Chemical-Induced Health Risks to Their Unborn Offspring?Biomedicines · 2024Review
- Preconceptional and in utero exposure of sheep to a real-life environmental chemical mixture disrupts key markers of energy metabolism in male offspring.Journal of neuroendocrinology · 2024Article
- Science evolves but outdated testing and static risk management in the US delay protection to human health.Frontiers in toxicology · 2024Article
- Review
- Chronic high-sugar diet in adulthood protects Caenorhabditis elegans from 6-OHDA-induced dopaminergic neurodegeneration.BMC biology · 2023Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
25 authors.
Philippe GrandjeanDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Robert BaroukiDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
David C BellingerDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Ludwine CasteleynDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Lisa H ChadwickDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Sylvaine CordierDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Ruth A EtzelDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Kimberly A GrayDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Eun-Hee HaDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Claudine JunienDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Margaret KaragasDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Toshihiro KawamotoDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
B Paige LawrenceDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Frederica P PereraDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Gail S PrinsDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Alvaro PugaDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Cheryl S RosenfeldDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
David H SherrDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Peter D SlyDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
William SukDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Qi SunDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Jorma ToppariDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Peter van den HazelDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Cheryl L WalkerDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Jerrold J HeindelDepartments of Environmental Health (P.G., D.C.B.) and Nutrition (Q.S.), Harvard T.H. Chan School of Public Health; Children's Hospital (D.C.B.), Harvard Medical School; and Channing Division of Network Medicine (Q.S.), Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115; Department of Environmental Medicine (P.G.), Institute of Public Health, University of Southern Denmark, 5000 Odense, Denmark; Institut National de la Santé et de la Recherche Médicale unit 1124 (R.B.), Université Paris Descartes, Hôpital Necker enfants malades, Assistance Publique-Hôpitaux de Paris, 75015 Paris, France; University of Leuven (L.C.), Center for Human Genetics, 3000 Leuven, Belgium; Division of Extramural Research and Training (L.H.C., K.A.G., W.S., J.J.H.), National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709; Institut National de la Santé et de la Recherche Médicale, Unit 1085 (S.C.), University Rennes I, F-35000 Rennes, France; Joseph J. Zilber School of Public Health (R.A.E.), University of Wisconsin, Milwaukee, Wisconsin 53201; Department of Preventive Medicine (E.-H.H.), School of Medicine, Ewha Womans University, Seoul 158-710, Republic of Korea; Institut National de la Recherche Agronomique (C.J.), MR Unité Mixte de Recherche 1198 Biologie du Développement et Reproduction, F-78350 Jouy-en-Josas, France; Université Versailles-St-Quentin (C.J.), 78000 Versailles, France; Children's Environmental Health and Disease Prevention Research Center and Department of Epidemiology, Geisel School of Medicine at Dartmouth (M.K.), Hanover, New Hampshire 03766; Department of Environmental Health (T.K.), University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan; Department of Environmental Medicine (B.P.L.), University of Rochester School of Medicine and Dentistry, Rochester, New York 14642; Department of Environmental Health Sciences and Columbia Center for Children's Environmental Heal
Funding
Project 3: Placental Biomarkers of Exposure and Outcome (Marsit)P01ES022832 · NIEHS · DARTMOUTH COLLEGE · PI MURRAY, CAROLYN J · 2013 to 2018
$4.7MTransgenerational exposures as modifiers of host defense against infectionR01ES023260 · NIEHS · UNIVERSITY OF ROCHESTER · PI LAWRENCE, B PAIGE · 2013 to 2017
$3.0MEffects of Arsenic on Human Prostate Stem Cells and Prostate Cancer RiskR01ES022071 · NIEHS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI HO, SHUK-MEI, PRINS, GAIL S · 2012 to 2016
$1.9MEnvironmental Influences on Epigenetic Immune ProgrammingR01ES017250 · NIEHS · UNIVERSITY OF ROCHESTER · PI LAWRENCE, B PAIGE · 2011 to 2015
$1.8MEstrogen Receptors in Human Prostate Stem-Progenitor CellsR01CA172220 · NCI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI PRINS, GAIL S · 2013 to 2017
$1.7MNCI NIH HHS R01 CA172220NIEHS NIH HHS P01 ES022832NIEHS NIH HHS R01 ES017250NIEHS NIH HHS R01 ES022071NIEHS NIH HHS R01 ES023260
Abstract
The Developmental Origins of Health and Disease (DOHaD) paradigm is one of the most rapidly expanding areas of biomedical research. Environmental stressors that can impact on DOHaD encompass a variety of environmental and occupational hazards as well as deficiency and oversupply of nutrients and energy. They can disrupt early developmental processes and lead to increased susceptibility to disease/dysfunctions later in life. Presentations at the fourth Conference on Prenatal Programming and Toxicity in Boston, in October 2014, provided important insights and led to new recommendations for research and public health action. The conference highlighted vulnerable exposure windows that can occur as early as the preconception period and epigenetics as a major mechanism than can lead to disadvantageous "reprogramming" of the genome, thereby potentially resulting in transgenerational effects. Stem cells can also be targets of environmental stressors, thus paving another way for effects that may last a lifetime. Current testing paradigms do not allow proper characterization of risk factors and their interactions. Thus, relevant exposure levels and combinations for testing must be identified from human exposure situations and outcome assessments. Testing of potential underpinning mechanisms and biomarker development require laboratory animal models and in vitro approaches. Only few large-scale birth cohorts exist, and collaboration between birth cohorts on a global scale should be facilitated. DOHaD-based research has a crucial role in establishing factors leading to detrimental outcomes and developing early preventative/remediation strategies to combat these risks.
Indexed as
Environmental ExposurePrenatal Exposure Delayed EffectsBostonEmbryologyEpigenesis, GeneticEpigenomicsFemaleHumansMaleMaternal ExposureObesityPlacentaPregnancyRisk FactorsStem CellsStress, Psychological
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