ReviewEndocrinology2015
Stress and Androgen Activity During Fetal Development.
Review in Endocrinology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06160037 (Influence of Prenatal and Early Childhood Home-Visiting by Nurses on Development of Chronic Disease), which is not on this map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Influence of Prenatal and Early Childhood Home-Visiting by Nurses on Development of Chronic Disease: 29-year Follow-Up of a Randomized Clinical Trial
Who cites it
47 citing papers in PubMed, 83 citations in OpenAlex.
- Early Home Visits and Health Outcomes in Low-Income Mothers and Offspring: 18-Year Follow-Up of a Randomized Clinical Trial.JAMA network open · 2024Trial
- Prenatal and Infancy Nurse Home Visiting and 18-Year Outcomes of a Randomized Trial.Pediatrics · 2019Trial
- Prenatal maternal stress is associated with alterations in the structural integrity of the hypothalamic-pituitary-gonadal axis 20 years later: Project Ice Storm.Human reproduction (Oxford, England) · 2026Article
- Timing matters: a prospective investigation of father absence and pubertal timing in girls and boys.Biology of sex differences · 2026Article
- Placental iron transport under maternal stress: a missing link in foetal programming and mental health.EBioMedicine · 2026Article
- Association between digit ratio (2D:4D) and right-left difference in 2D:4D ratio with breast cancer risk: multicentre case-control study from India.Scientific reports · 2025Article
- Placental mitochondrial calcium uniporter modulates offspring susceptibility to metabolic dysfunction.Molecular metabolism · 2025Article
- Maternal polycystic ovarian syndrome and offspring psychopathology and neurodevelopment.Human reproduction (Oxford, England) · 2025Review
- Association of preconception maternal glucocorticoid concentrations with sex ratio at birth: Evidence from a prospective cohort study.Annals of epidemiology · 2025Article
- Did Premodern Wars Impact Sex Ratios at Birth? The Case of 19th-Century Basque Country.Human nature (Hawthorne, N.Y.) · 2025Article
- Testosterone mediates life-history trade-offs in female mammals.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Maternal Hyperandrogenemia and the Long-Term Neuropsychological, Sex Developmental, and Metabolic Effects on Offspring.International journal of molecular sciences · 2025Review
- Association of Prenatal Depression With Second to Fourth Digit Ratio in Children Aged 4 and 6 Years.Depression and anxiety · 2025Article
- Review
- Translational models of stress and resilience: An applied neuroscience methodology review.Neuroscience applied · 2024Review
- Prenatal exposures to phthalates and life events stressors in relation to child behavior at age 4-6: A combined cohort analysis.Environment international · 2024Article
- Effects of an App-Based Mindfulness Intervention during Pregnancy on the Infant's Prenatal Androgen Exposure: A Randomized Controlled Pilot Trial.Journal of clinical medicine · 2023Article
- Symptoms of maternal psychological distress during pregnancy: sex-specific effects for neonatal morbidity.Journal of perinatal medicine · 2022Article
- Trends in Research of Prenatal Stress From 2011 to 2021: A Bibliometric Study.Frontiers in pediatrics · 2022Article
- Parental Separation and Semen Quality in Young Men: A Population-Based Cohort Study.Clinical epidemiology · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Prenatal stress is known to alter hypothalamic-pituitary-adrenal axis activity, and more recent evidence suggests that it may also affect androgen activity. In animal models, prenatal stress disrupts the normal surge of testosterone in the developing male, whereas in females, associations differ by species. In humans, studies show that (1) associations between prenatal stress and child outcomes are often sex-dependent, (2) prenatal stress predicts several disorders with notable sex differences in prevalence, and (3) prenatal exposure to stressful life events may be associated with masculinized reproductive tract development and play behavior in girls. In this minireview, we examine the existing literature on prenatal stress and androgenic activity and present new, preliminary data indicating that prenatal stress may also modify associations between prenatal exposure to diethylhexyl phthalate, (a synthetic, antiandrogenic chemical) and reproductive development in infant boys. Taken together, these data support the hypothesis that prenatal exposure to both chemical and nonchemical stressors may alter sex steroid pathways in the maternal-placental-fetal unit and ultimately alter hormone-dependent developmental endpoints.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.