ArticlePloS one2015
Smooth Muscle Cell Genome Browser: Enabling the Identification of Novel Serum Response Factor Target Genes.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
36 citing papers in PubMed, 60 citations in OpenAlex.
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- Interstitial cells of the sip syncytium regulate basal membrane potential in murine gastric corpus.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024Article
- CaPhysiological reviews · 2024Review
- Age-associated changes in lineage composition of the enteric nervous system regulate gut health and disease.eLife · 2023Article
- Neural targets of the enteric dopaminergic system in regulating motility of rat proximal colon.Pflugers Archiv : European journal of physiology · 2023Article
- Transcriptome and Proteome Profiling of Primary Human Gastric Interstitial Cells of Cajal Predicts Pacemaker Networks.Journal of neurogastroenterology and motility · 2023Article
- Actin-related protein 5 suppresses the cooperative activation of cardiac gene transcription by myocardin and MEF2.FEBS open bio · 2023Article
- Single Nucleus Sequencing of Human Colon Myenteric Plexus-Associated Visceral Smooth Muscle Cells, Platelet Derived Growth Factor Receptor Alpha Cells, and Interstitial Cells of Cajal.Gastro hep advances · 2023Article
- CaThe Journal of physiology · 2022Article
- Metalloendopeptidase ADAM-like Decysin 1 (ADAMDEC1) in Colonic Subepithelial PDGFRαInternational journal of molecular sciences · 2022Article
- Crosstalk Between Macrophages and Vascular Smooth Muscle Cells in Atherosclerotic Plaque Stability.Arteriosclerosis, thrombosis, and vascular biology · 2022Review
- Transcriptome profiling of subepithelial PDGFRα cells in colonic mucosa reveals several cell-selective markers.PloS one · 2022Article
- Neurotransmitters responsible for purinergic motor neurotransmission and regulation of GI motility.Autonomic neuroscience : basic & clinical · 2021Article
- A novel DNA methylation signature is associated with androgen receptor activity and patient prognosis in bone metastatic prostate cancer.Clinical epigenetics · 2021Article
- Delineating the heterogeneity of matrix-directed differentiation toward soft and stiff tissue lineages via single-cell profiling.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Extracellular metabolism of the enteric inhibitory neurotransmitter β-nicotinamide adenine dinucleotide (β-NAD) in the murine colon.The Journal of physiology · 2020Article
- Cellular and molecular architecture of the intestinal stem cell niche.Nature cell biology · 2020Review
- A novel postsynaptic signal pathway of sympathetic neural regulation of murine colonic motility.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020Article
- Generation of an enteric smooth muscle cell line from the pig ileum.Journal of animal science · 2020Article
- Norepinephrine Has Dual Effects on Human Colonic Contractions Through Distinct Subtypes of Alpha 1 Adrenoceptors.Cellular and molecular gastroenterology and hepatology · 2020Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
Abstract
Genome-scale expression data on the absolute numbers of gene isoforms offers essential clues in cellular functions and biological processes. Smooth muscle cells (SMCs) perform a unique contractile function through expression of specific genes controlled by serum response factor (SRF), a transcription factor that binds to DNA sites known as the CArG boxes. To identify SRF-regulated genes specifically expressed in SMCs, we isolated SMC populations from mouse small intestine and colon, obtained their transcriptomes, and constructed an interactive SMC genome and CArGome browser. To our knowledge, this is the first online resource that provides a comprehensive library of all genetic transcripts expressed in primary SMCs. The browser also serves as the first genome-wide map of SRF binding sites. The browser analysis revealed novel SMC-specific transcriptional variants and SRF target genes, which provided new and unique insights into the cellular and biological functions of the cells in gastrointestinal (GI) physiology. The SRF target genes in SMCs, which were discovered in silico, were confirmed by proteomic analysis of SMC-specific Srf knockout mice. Our genome browser offers a new perspective into the alternative expression of genes in the context of SRF binding sites in SMCs and provides a valuable reference for future functional studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.