ArticleACS biomaterials science & engineering2015
Functionalized α-Helical Peptide Hydrogels for Neural Tissue Engineering.
Article in ACS biomaterials science & engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 73 citations in OpenAlex.
- Biomaterials for CNS disorders: a review of development from traditional methods to AI-assisted optimization.Journal of materials science. Materials in medicine · 2025Review
- Generation of Active Neurons from Mouse Embryonic Stem Cells Using Retinoic Acid and Purmorphamine.International journal of molecular sciences · 2025Article
- A Roadmap of Peptide-Based Materials in Neural Regeneration.Advanced healthcare materials · 2025Review
- Self-Assembling Peptide Hydrogels as Functional Tools to Tackle Intervertebral Disc Degeneration.Gels (Basel, Switzerland) · 2022Review
- Enhancing Peptide Biomaterials for Biofabrication.Polymers · 2021Review
- Glycosylation of a Nonfibrillizing Appendage Alters the Self-Assembly Pathway of a Synthetic β-Sheet Fibrillizing Peptide.The journal of physical chemistry. B · 2021Article
- Peptide-based scaffolds for the culture and maintenance of primary human hepatocytes.Scientific reports · 2021Article
- De Novo Designed Peptide and Protein Hairpins Self-Assemble into Sheets and Nanoparticles.Small (Weinheim an der Bergstrasse, Germany) · 2021Review
- Self-assembling multidomain peptide hydrogels accelerate peripheral nerve regeneration after crush injury.Biomaterials · 2021Article
- Perspective Insights to Bio-Nanomaterials for the Treatment of Neurological Disorders.Frontiers in bioengineering and biotechnology · 2021Review
- Recent advances in design and applications of biomimetic self-assembled peptide hydrogels for hard tissue regeneration.Bio-design and manufacturing · 2021Review
- Charge guides pathway selection in β-sheet fibrillizing peptide co-assembly.Communications chemistry · 2020Article
- Biomaterials in Neurodegenerative Disorders: A Promising Therapeutic Approach.International journal of molecular sciences · 2020Review
- Self-assemble peptide biomaterials and their biomedical applications.Bioactive materials · 2019Review
- Self-Assembling Peptides as Extracellular Matrix Mimics to Influence Stem Cell's Fate.Frontiers in chemistry · 2019Review
- Silsesquioxane polymer as a potential scaffold for laryngeal reconstruction.Materials science & engineering. C, Materials for biological applications · 2018Article
- Article
- Harnessing supramolecular peptide nanotechnology in biomedical applications.International journal of nanomedicine · 2017Review
- Biosynthesis and Characterization of Cross-Linked Fmoc Peptide-Based Hydrogels for Drug Delivery Applications.Gels (Basel, Switzerland) · 2015Article
- Synthetic Peptides as Protein Mimics.Frontiers in bioengineering and biotechnology · 2015Review
Corrections and comments
- Erratum issued
Authors and funding
11 authors at 4 institutions in 1 country.
Funding
Abstract
Trauma to the central and peripheral nervous systems often lead to serious morbidity. Current surgical methods for repairing or replacing such damage have limitations. Tissue engineering offers a potential alternative. Here we show that functionalized α-helical-peptide hydrogels can be used to induce attachment, migration, proliferation and differentiation of murine embryonic neural stem cells (NSCs). Specifically, compared with undecorated gels, those functionalized with Arg-Gly-Asp-Ser (RGDS) peptides increase the proliferative activity of NSCs; promote their directional migration; induce differentiation, with increased expression of microtubule-associated protein-2, and a low expression of glial fibrillary acidic protein; and lead to the formation of larger neurospheres. Electrophysiological measurements from NSCs grown in RGDS-decorated gels indicate developmental progress toward mature neuron-like behavior. Our data indicate that these functional peptide hydrogels may go some way toward overcoming the limitations of current approaches to nerve-tissue repair.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.