Evidence map›Paper›PMID 26240814›Full record

ReviewBioMed research international2015

Update on Biomarkers for the Detection of Endometriosis.

Amelie Fassbender, Richard O Burney, Dorien F O, Thomas D'Hooghe, Linda Giudice

Abstract readReview
In one paragraph

Review in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed, 5 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed, 5 syntheses or guidelines pooled it.

  1. Combination of the non-invasive tests for the diagnosis of endometriosis.The Cochrane database of systematic reviews · 2016
    Pooled it
  2. Blood biomarkers for the non-invasive diagnosis of endometriosis.The Cochrane database of systematic reviews · 2016
    Pooled it
  3. Endometrial biomarkers for the non-invasive diagnosis of endometriosis.The Cochrane database of systematic reviews · 2016
    Pooled it
  4. Urinary biomarkers for the non-invasive diagnosis of endometriosis.The Cochrane database of systematic reviews · 2015
    Pooled it
  5. Pooled it
  6. Review
  7. Article
  8. Article
  9. Article
  10. Endometriosis: Challenges in Clinical Molecular Diagnostics and Treatment.International journal of molecular sciences · 2025
    Review
  11. Review
  12. Article
  13. Article
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2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Amelie FassbenderDepartment of Development and Regeneration, Organ Systems, KU Leuven, 3000 Leuven, Belgium ; Department of Obstetrics and Gynaecology, Leuven University Fertility Centre, University Hospital Leuven, 3000 Leuven, Belgium.
Richard O BurneyDepartments of Obstetrics and Gynecology and Clinical Investigation, Madigan Healthcare System, Tacoma, WA 98431, USA.
Dorien F ODepartment of Development and Regeneration, Organ Systems, KU Leuven, 3000 Leuven, Belgium ; Department of Obstetrics and Gynaecology, Leuven University Fertility Centre, University Hospital Leuven, 3000 Leuven, Belgium.
Thomas D'HoogheDepartment of Development and Regeneration, Organ Systems, KU Leuven, 3000 Leuven, Belgium ; Department of Obstetrics and Gynaecology, Leuven University Fertility Centre, University Hospital Leuven, 3000 Leuven, Belgium ; Division of Reproductive Biology, Institute of Primate Research, Karen, Nairobi 00 100, Kenya.
Linda GiudiceDepartment of Obstetrics and Gynecology, University of California San Francisco, San Francisco, CA 94015, USA.

Funding

Project 4: Human Endometrial Programming for Successful ImplantationP50HD055764 · NICHD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GIUDICE, LINDA C · 2014 to 2022
$16.4M
NICHD NIH HHS P50 HD055764
6 · The paper itself

Abstract

Endometriosis is histologically characterized by the displacement of endometrial tissue to extrauterine locations including the pelvic peritoneum, ovaries, and bowel. An important cause of infertility and pelvic pain, the individual and global socioeconomic burden of endometriosis is significant. Laparoscopy remains the gold standard for the diagnosis of the condition. However, the invasive nature of surgery, coupled with the lack of a laboratory biomarker for the disease, results in a mean latency of 7-11 years from onset of symptoms to definitive diagnosis. Unfortunately, the delay in diagnosis may have significant consequences in terms of disease progression. The discovery of a sufficiently sensitive and specific biomarker for the nonsurgical detection of endometriosis promises earlier diagnosis and prevention of deleterious sequelae and represents a clear research priority. In this review, we describe and discuss the current status of biomarkers of endometriosis in plasma, urine, and endometrium.

Indexed as

BiomarkersEarly DiagnosisEndometriosisEndometriumFemaleHumansReproducibility of ResultsSensitivity and SpecificityBiomarkers

Identifiers

PMID26240814
PMCPMC4512573

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.