ReviewClinical endoscopy2015
Diagnostic and Treatment Approaches for Refractory Peptic Ulcers.
Review in Clinical endoscopy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 42 citations in OpenAlex.
- Treatment outcomes and determinants of refractory peptic ulcer disease in children: A prospective study from Vietnam.Journal of pediatric gastroenterology and nutrition · 2026Article
- Bioinspired Quinoline-2 Derivatives Based on the Natural Alkaloid 2-Phenylquinoline fromMolecules (Basel, Switzerland) · 2026Article
- Acid peptic disorder compass: An Indian expert consensus on comprehensive management.World journal of gastrointestinal pharmacology and therapeutics · 2026Review
- Complete blood count-derived inflammatory indices: A noninvasive aid for risk stratification in gastric ulcer.World journal of gastroenterology · 2026Article
- Etiology and Therapeutic Strategies for Refractory Peptic Ulcers: A Comprehensive Review.The Korean journal of helicobacter and upper gastrointestinal research · 2025Review
- Unravelling Peptic Ulcers: Comprehensive Insights into Etiology, Diagnosis, Screening Techniques, and Treatment.Current pharmaceutical design · 2025Review
- The Gastroprotective Effect of Hydrogen-Rich Coral Calcium in a Mouse Model of Peptic Ulcer Disease.Drug design, development and therapy · 2025Article
- The treatment principles and targets for intestinal Behcet's disease.Therapeutic advances in gastroenterology · 2023Review
- Evaluation of proton pump inhibitor administration in hospitalized dogs in a tertiary referral hospital.Journal of veterinary internal medicine · 2022Article
- Therapeutic approach of adipose-derived mesenchymal stem cells in refractory peptic ulcer.Stem cell research & therapy · 2021Review
- Rosmarinic acid prevents gastric ulcers via sulfhydryl groups reinforcement, antioxidant and immunomodulatory effects.Naunyn-Schmiedeberg's archives of pharmacology · 2020Article
- IgG4-related Disease Manifesting as Gastroduodenal Ulcer Diagnosed by an Endoscopic Biopsy.Internal medicine (Tokyo, Japan) · 2020Article
- Tadalafil-Loaded Limonene-Based Orodispersible Tablets: Formulation, in vitro Characterization and in vivo Appraisal of Gastroprotective Activity.International journal of nanomedicine · 2020Article
- Highlights from the 52nd Seminar of the Korean Society of Gastrointestinal Endoscopy.Clinical endoscopy · 2015Review
- Duodenal Ulceration following Holmium Laser Lithotripsy.Case reports in gastroenterologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Refractory peptic ulcers are defined as ulcers that do not heal completely after 8 to 12 weeks of standard anti-secretory drug treatment. The most common causes of refractory ulcers are persistent Helicobacter pylori infection and use of nonsteroidal anti-inflammatory drugs (NSAIDs). Simultaneous use of two or more H. pylori diagnostic methods are recommended for increased sensitivity. Serologic tests may be useful for patients currently taking proton pump inhibitors (PPIs) or for suspected false negative results, as they are not affected by PPI use. NSAID use should be discontinued when possible. Platelet cyclooxygenase activity tests can confirm surreptitious use of NSAIDs or aspirin. Cigarette smoking can delay ulcer healing. Therefore, patients who smoke should be encouraged to quit. Zollinger-Ellison syndrome (ZES) is a rare but important cause of refractory gastroduodenal ulcers. Fasting plasma gastrin levels should be checked if ZES is suspected. If an ulcer is refractory despite a full course of standard PPI treatment, the dose should be doubled and administration of another type of PPI considered.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.