ArticleAsia Pacific allergy2015
Repeat oral food challenges in peanut and tree nut allergic children with a history of mild/moderate reactions.
Article in Asia Pacific allergy, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Association of STAT6 gene variants with food allergy diagnosed by double-blind placebo-controlled food challenges.Allergy · 2018Trial
- Eliciting Dose and Safety Outcomes From a Large Dataset of Standardized Multiple Food Challenges.Frontiers in immunology · 2018Trial
- Decoding Early Clues: Immune Mechanisms, Prevention, Diagnosis, and Treatment of IgE-Mediated Peanut and Tree Nut Allergy in Children.Biomedicines · 2025Review
- Estimating Cost-Effectiveness of Confirmatory Oral Food Challenges in the Diagnosis of Children With Food Allergy.Global pediatric health · 2019Article
- Early stent thrombosis secondary to food allergic reaction: Kounis syndrome following rice pudding ingestion.World journal of cardiology · 2017Article
- Crossing the threshold: can outcome data from food challenges be used to predict risk of anaphylaxis in the community?Allergy · 2017Article
- Multicentre Double-Blind Placebo-Controlled Food Challenge Study in Children Sensitised to Cashew Nut.PloS one · 2016Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn peanut and tree nut allergic children a history of anaphylaxis is associated with subsequent severe reactions.
objectiveWe aimed to prospectively rechallenge peanut and tree nut allergic children with a history of mild/moderate reactions to assess their allergy over time.
methodsIn this cohort study peanut and tree nut allergic children with a history of mild/moderate reactions during a controlled oral challenge were invited to have a follow-up oral challenge to the same food at least 1 year later.
resultsTwenty-six children participated in the study. The mean time interval between the first and second challenge for all participants was 35.5 months. Peanut or tree nut allergy resolved in 38.5% of participants. Those with persistent peanut or tree nut allergy showed a decrease in their reaction threshold and/or increased severity in 81% of cases. There were no demographic features or skin test results that were predictive of changes in severity over time.
conclusionPeanut and tree nut allergic children with a history of mild/moderate reactions who remained allergic demonstrated a high rate of more severe reactions and/or reduced thresholds upon rechallenge over a year later, however, the rate of resolution of allergy in this group may be higher than previously reported.
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