ArticleSpringerPlus2015
Osteomyelitis due to Clostridium innocuum in a patient with acute lymphoblastic leukemia: case report and literature review.
Article in SpringerPlus, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 15 citations in OpenAlex.
- Impact of vancomycin and Clostridioides difficile on the secretome and pathogenicity of Clostridium innocuum.Medical microbiology and immunology · 2025Article
- Case-Control Study of Clostridium innocuum Infection, Taiwan.Emerging infectious diseases · 2022Article
- Clostridium innocuum: Microbiological and clinical characteristics of a potential emerging pathogen.Anaerobe · 2021Review
- Surgical treatment of recurrent acute lymphoblastic leukemia with humeral osteomyelitis as the first symptom: a case report and literature review.Annals of translational medicine · 2021Article
- Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionClostridium innocuum is an anaerobic Gram-positive bacterium, unable to produce toxins and rarely causes infections. We report the first case of C. innocuum osteomyelitis and bacteremia in a patient with acute lymphoblastic leukemia (ALL). Findings were compared with previously reported cases of C. innocuum infections in immunocompromised patients, e.g., patients with acquired immune deficiency syndrome, leukemia, and organ transplantation. CASE DESCRIPTION: A 32-year-old Japanese male was admitted for persistent low-grade fever and purpura lasting for 1 month. Complete blood counts and cytogenetic analysis identified Ph1-positive ALL, which was successfully treated using chemotherapy. However, the patient developed high fever and lumbar pain during complete remission. Fluorodeoxyglucose-positron emission tomography and computed tomography demonstrated osteomyelitis. C. innocuum was identified as the causative agent and the patient was successfully treated using antibiotic therapy. DISCUSSION AND EVALUATION: We performed a literature review revealing a number of common aspects to the clinical presentation of C. innocuum infection and an association with various comorbidities. Further, we highlight the most efficient diagnostic and treatment strategies for C. innocuum osteomyelitis.
conclusionsClostridium innocuum can be a causative pathogen of osteomyelitis and bacteremia in immunocompromised patients.
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