ArticleEvolutionary applications2015
The effects of spatial structure, frequency dependence and resistance evolution on the dynamics of toxin-mediated microbial invasions.
Article in Evolutionary applications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Novel killer yeasts and toxins from the gardens of fungus-growing ants.Applied and environmental microbiology · 2026Article
- Intraspecies warfare restricts strain coexistence in human skin microbiomes.Nature microbiology · 2025Article
- Intraspecies warfare restricts strain coexistence in human skin microbiomes.bioRxiv : the preprint server for biology · 2025Article
- Article
- Bacterial defences: mechanisms, evolution and antimicrobial resistance.Nature reviews. Microbiology · 2023Review
- Siderophores drive invasion dynamics in bacterial communities through their dual role as public good versus public bad.Ecology letters · 2022Article
- Antagonism between killer yeast strains as an experimental model for biological nucleation dynamics.eLife · 2021Article
- Experimental Evolution of Interference Competition.Frontiers in microbiology · 2021Article
- Investigating the dynamics of microbial consortia in spatially structured environments.Nature communications · 2020Article
- The Effects of Colicin Production Rates on Allelopathic Interactions inMicroorganisms · 2019Article
- Experimental Design, Population Dynamics, and Diversity in Microbial Experimental Evolution.Microbiology and molecular biology reviews : MMBR · 2018Review
- Modelling upper respiratory tract diseases: getting grips on host-microbe interactions in chronic rhinosinusitis using in vitro technologies.Microbiome · 2018Review
- Comparative Genomics ofFrontiers in microbiology · 2018Article
- An ecosystem framework for understanding and treating disease.Evolution, medicine, and public health · 2018Review
- Whole-Genome Sequence ofGenome announcements · 2017Article
- Bacteriocins and the assembly of natural Pseudomonas fluorescens populations.Journal of evolutionary biology · 2017Article
- Deferred Growth Inhibition Assay to Quantify the Effect of Bacteria-derived Antimicrobials on Competition.Journal of visualized experiments : JoVE · 2016Article
- Beyond killing: Can we find new ways to manage infection?Evolution, medicine, and public health · 2016Review
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Recent evidence suggests that interference competition between bacteria shapes the distribution of the opportunistic pathogen Staphylococcus aureus in the lower nasal airway of humans, either by preventing colonization or by driving displacement. This competition within the nasal microbial community would add to known host factors that affect colonization. We tested the role of toxin-mediated interference competition in both structured and unstructured environments, by culturing S. aureus with toxin-producing or nonproducing Staphylococcus epidermidis nasal isolates. Toxin-producing S. epidermidis invaded S. aureus populations more successfully than nonproducers, and invasion was promoted by spatial structure. Complete displacement of S. aureus was prevented by the evolution of toxin resistance. Conversely, toxin-producing S. epidermidis restricted S. aureus invasion. Invasion of toxin-producing S. epidermidis populations by S. aureus resulted from the evolution of toxin resistance, which was favoured by high initial frequency and low spatial structure. Enhanced toxin production also evolved in some invading populations of S. epidermidis. Toxin production therefore promoted invasion by, and constrained invasion into, populations of producers. Spatial structure enhanced both of these invasion effects. Our findings suggest that manipulation of the nasal microbial community could be used to limit colonization by S. aureus, which might limit transmission and infection rates.
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