ArticleElectrolyte & blood pressure : E & BP2015
A Case of Osmotic Demyelination Presenting with Severe Hypernatremia.
Article in Electrolyte & blood pressure : E & BP, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Cytotoxic Lesions of the Corpus Callosum Preceding Osmotic Demyelination Syndrome in Hypernatremia and Hyperosmolar Hyperglycemic State: A Case Report.Electrolyte & blood pressure : E & BP · 2025Article
- An Unusual Case of a Central Pontine Myelinolysis Associated with Primary Splenic Diffuse Large B-cell Lymphoma.Internal medicine (Tokyo, Japan) · 2025Article
- Unmasking Osmotic Demyelination Syndrome/Extrapontine Myelinolysis in Acute Intermittent Porphyria: Preventable Complications-Challenges in Diagnosis and Management.Annals of Indian Academy of Neurology · 2025Article
- Osmotic Demyelination Syndrome Associated with Uremia and Elevated Serum Osmolality.Neurocritical care · 2024Article
- Hyperchloremia and Hypernatremia Decreased Microglial and Neuronal Survival during Oxygen-Glucose Deprivation/Reperfusion.Biomedicines · 2024Article
- Impact of pre-bypass ultrafiltration on prime values and clinical outcomes in neonatal and infant cardiopulmonary bypass.The journal of extra-corporeal technology · 2023Article
- Osmotic Demyelination Syndrome in a High-Risk Patient Despite Cautious Correction of Hyponatremia.Electrolyte & blood pressure : E & BP · 2023Article
- Imaging of extrapontine myelinolysis preceding central pontine myelinolysis in a case of ornithine transcarbamylase deficiency with hyperammonaemia and hypokalaemia.BMJ neurology open · 2022Article
- Postpartum Hypernatremia with Extrapontine Rhabdomyelinolysis: A Case Report.Qatar medical journal · 2022Article
- Topiramate-induced severe electrolyte abnormalities and hypernatremia leading to central pontine myelinolysis.BMJ case reports · 2021Article
- Central Pontine Myelinolysis in a Normonatremic Patient with Depression.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2021Article
- Alcoholic pontine myelinolysis: beware the stroke mimic.BJR case reports · 2021Article
- Review
- Treatment response in osmotic demyelination syndrome presenting as severe parkinsonism, ptosis and gaze palsy.BMJ case reports · 2018Article
- Caudal and Lentiform nuclei Myelinolysis following Endoscopical surgery for pediatric Craniopharyngioma: two cases report and literature review.Chinese neurosurgical journal · 2018Article
- Therapeutic Effect of Steroids in Osmotic Demyelination of Infancy.Child neurology open · 2018Article
- Case Report: Severe hypernatremia from psychogenic adipsia.F1000Research · 2017Article
- Wine Glass Sign and Empty Delta Sign: A Rare Imaging Presentation of Postpartum Encephalopathy in Dehydration.Journal of clinical and diagnostic research : JCDR · 2016Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Osmotic demyelination syndrome is a demyelinating disorder associated with rapid correction of hyponatremia. But, it rarely occurs in acute hypernatremia, and it leads to permanent neurologic symptoms and is associated with high mortality. A 44-year-old woman treated with alternative medicine was admitted with a history of drowsy mental status. Severe hypernatremia (197mEq/L) with hyperosmolality (415mOsm/kgH2O) was evident initially and magnetic resonance imaging revealed a high signal intensity lesion in the pons, consistent with central pontine myelinolysis. She was treated with 0.45% saline and 5% dextrose water and intravenous corticosteroids. Serum sodium normalized and her clinical course gradually improved. Brain lesion of myelinolysis also improved in a follow-up imaging study. This is the first report of a successful treatment of hypernatremia caused by iatrogenic salt intake, and it confirms the importance of adequate fluid supplementation in severe hypernatremia.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.