ArticleStem cells international2015
In Vitro Effects of Strontium on Proliferation and Osteoinduction of Human Preadipocytes.
Article in Stem cells international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Does the incorporation of strontium into calcium phosphate improve bone repair? A meta-analysis.BMC oral health · 2022Pooled it
- Fabrication of Lithium/Strontium-Releasing Smart Bioactive Glasses with Anti-Inflammatory and Osteogenic Effects Tailored to Pathological Stages.Macromolecular bioscience · 2025Article
- Mg-Ca-Sr Biodegradable Alloys for Medical Applications: Production, Biomaterials' Properties Characterization, and In Vitro and In Vivo Biocompatibility Evaluation.Bioengineering (Basel, Switzerland) · 2025Article
- GelMA-GelDopa-Sr double-network hydrogel promotes skin regeneration by enhancing angiogenesis and macrophage polarization.Frontiers in bioengineering and biotechnology · 2025Article
- Influence of Strontium on the Biological Behavior of Bioactive Glasses for Bone Regeneration.Materials (Basel, Switzerland) · 2023Review
- Mesoporous Bioactive Glass-Incorporated Injectable Strontium-Containing Calcium Phosphate Cement Enhanced Osteoconductivity in a Critical-Sized Metaphyseal Defect in Osteoporotic Rats.Bioengineering (Basel, Switzerland) · 2023Article
- The Role of Trace Elements and Minerals in Osteoporosis: A Review of Epidemiological and Laboratory Findings.Biomolecules · 2023Review
- Article
- Multifunctional Gel Films of Marine Polysaccharides Cross-Linked with Poly-Metal Ions for Wound Healing.Pharmaceuticals (Basel, Switzerland) · 2022Article
- PH-responsive strontium nanoparticles for targeted gene therapy against mammary carcinoma cells.Asian journal of pharmaceutical sciences · 2021Article
- Antibacterial coating of tooth surface with ion-releasing pre-reacted glass-ionomer (S-PRG) nanofillers.Heliyon · 2021Article
- Facilitated and Controlled Strontium Ranelate Delivery Using GCS-HA Nanocarriers Embedded into PEGDA Coupled with Decortication Driven Spinal Regeneration.International journal of nanomedicine · 2021Article
- Characterization of Skeletal Muscle Endocrine Control in an In Vitro Model of Myogenesis.Calcified tissue international · 2020Article
- Human Mesenchymal Stem Cell Combined with a New Strontium-Enriched Bioactive Glass: AnMaterials (Basel, Switzerland) · 2019Article
- Article
- Synthesis and characterization of CaSr-Metal Organic Frameworks for biodegradable orthopedic applications.Scientific reports · 2019Article
- A New Bioactive Glass/Collagen Hybrid Composite for Applications in Dentistry.Materials (Basel, Switzerland) · 2019Article
- Strontium Promotes the Proliferation and Osteogenic Differentiation of Human Placental Decidual Basalis- and Bone Marrow-Derived MSCs in a Dose-Dependent Manner.Stem cells international · 2019Article
- Development and Characterization of Sr-Containing Glass-Ceramic Composites Based on Biogenic Hydroxyapatite.Nanoscale research letters · 2018Article
- Bioactive Glasses: Where Are We and Where Are We Going?Journal of functional biomaterials · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Development of tools to be used for in vivo bone tissue regeneration focuses on cellular models and differentiation processes. In searching for all the optimal sources, adipose tissue-derived mesenchymal stem cells (hADSCs or preadipocytes) are able to differentiate into osteoblasts with analogous characteristics to bone marrow mesenchymal stem cells, producing alkaline phosphatase (ALP), collagen, osteocalcin, and calcified nodules, mainly composed of hydroxyapatite (HA). The possibility to influence bone differentiation of stem cells encompasses local and systemic methods, including the use of drugs administered systemically. Among the latter, strontium ranelate (SR) represents an interesting compound, acting as an uncoupling factor that stimulates bone formation and inhibits bone resorption. The aim of our study was to evaluate the in vitro effects of a wide range of strontium (Sr(2+)) concentrations on proliferation, ALP activity, and mineralization of a novel finite clonal hADSCs cell line, named PA20-h5. Sr(2+) promoted PA20-h5 cell proliferation while inducing the increase of ALP activity and gene expression as well as HA production during in vitro osteoinduction. These findings indicate a role for Sr(2+) in supporting bone regeneration during the process of skeletal repair in general, and, more specifically, when cell therapies are applied.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.