ArticleKorean journal of ophthalmology : KJO2015
Ocular Manifestations of Acquired Immunodeficiency Syndrome.
Article in Korean journal of ophthalmology : KJO, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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11 citing papers in PubMed, 21 citations in OpenAlex.
- Beyond CD4: Posterior segment findings and virologic-immunologic predictors in highly active antiretroviral therapy-naïve HIV patients.Indian journal of ophthalmology · 2026Article
- Treatment with Subtenon and Intravitreal Triamcinolone Acetonide for Cystoid Macular Edema after Cytomegalovirus Retinitis: A Case Report.Korean journal of ophthalmology : KJO · 2025Article
- Ocular Manifestations of Perinatal HIV Infection in Kenyan Children on HAART: A Cross-Sectional Comparative Study.Clinical ophthalmology (Auckland, N.Z.) · 2025Article
- Dry eye: A hospital-based sociodemographic, risk and clinical classification profile.Health SA = SA Gesondheid · 2025Article
- Combined Cytomegalovirus Retinitis and Vitreous Hemorrhage in an Immunocompromised Patient.Case reports in ophthalmological medicine · 2025Article
- Venous thromboembolism in viral diseases: A comprehensive literature review.Health science reports · 2023Article
- The value and implementation of routine ophthalmic examination in the era of HAART.EClinicalMedicine · 2021Article
- Increased incidence of glaucoma medication usage in middle-aged Australian males taking antiretroviral medication - a population-based study.Journal of ophthalmic inflammation and infection · 2020Article
- Intraocular pressure in patients with human immunodeficiency virus, correlation with TCD4, viral load and demographic characteristics: a case-control study.Clinical ophthalmology (Auckland, N.Z.) · 2019Article
- Fundus manifestations and HIV viral loads of AIDS patients before and after HAART.International journal of ophthalmology · 2019Article
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5 authors at 1 institution in 1 country.
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Abstract
purposeTo investigate the patterns and risk factors of the ocular manifestations of acquired immunodeficiency syndrome (AIDS) and their correlation with CD4+ count in the era of highly active antiretroviral therapy (HAART).
methodsThis retrospective study examined 127 AIDS patients who presented to Soonchunhyang University Hospital. Data were collected from patient interviews, clinical examinations, and laboratory investigations. Ophthalmologic examinations included the best-corrected visual acuity, intraocular pressure, anterior segment and adnexal examination, and dilated fundus examination.
resultsOf the 127 patients with AIDS, 118 were on HAART and 9 were not. The mean CD4+ count was 266.7 ± 209.1 cells/µL. There were ocular manifestations in 61 patients (48.0%). The incidence of anterior segment manifestations was higher than posterior segment manifestations at 28.3% and 19.7%, respectively. The mean CD4+ count was significantly (p < 0.05) lower in the patients with posterior versus anterior segment ocular manifestations. The most common ocular manifestation was retinal microvasculopathy (15.0%), followed by keratoconjunctivitis sicca (14.2%), conjunctival microvasculopathy (9.4%), cytomegalovirus retinitis (3.1%), herpes zoster ophthalmicus (2.4%), and blepharitis (1.6%). Retinal microvasculopathy and cytomegalovirus retinitis were common in patients with CD4+ counts <200 cells/µL, while keratoconjunctivitis sicca and conjunctival microvasculopathy were common in patients with CD4+ counts of 200 to 499 cells/µL. There was a significant (p < 0.05) association between ocular manifestation and CD4+ count or age.
conclusionsThe introduction of HAART has changed the landscape of ocular presentations in patients with AIDS. In this study, anterior segment and external ocular manifestations occurred more frequently than posterior segment manifestations. Also, the mean CD4+ count was significantly lower in patients with posterior segment ocular manifestations versus anterior segment ocular manifestations. We found that CD4+ count and age >35 years were independent risk factors for developing ocular manifestations.
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