Evidence map›Paper›PMID 26240427›Full record

ReviewPhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015

Illuminating neural circuits and behaviour in Caenorhabditis elegans with optogenetics.

Christopher Fang-Yen, Mark J Alkema, Aravinthan D T Samuel

Open access · bronzeAbstract readReview
In one paragraph

Review in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 54 citations in OpenAlex.

  1. From small brains to smart machines: translatingFrontiers in neural circuits · 2026
    Review
  2. Article
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  4. Review
  5. Article
  6. Article
  7. Article
  8. Neuronal overexpression of hTDP-43 inmicroPublication biology · 2023
    Article
  9. Neuronal overexpression of human TDP-43 inmicroPublication biology · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Clues to basis of exploratory behaviour of thePhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Review
  16. Article
  17. Demonstrating Connections Between Neuron Signaling and Behavior usingJournal of undergraduate neuroscience education : JUNE : a publication of FUN, Faculty for Undergraduate Neuroscience · 2018
    Article
  18. Olfactory circuits and behaviors of nematodes.Current opinion in neurobiology · 2016
    Review
  19. Review
  20. eLife · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Christopher Fang-YenDepartment of Bioengineering, School of Engineering and Applied Science, University of Pennsylvania, Philadelphia, PA 19104, USA Department of Neuroscience, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA fangyen@seas.upenn.edu.
Mark J AlkemaDepartment of Neurobiology, University of Massachusetts Medical School, Worcester, MA 01655, USA.
Aravinthan D T SamuelDepartment of Physics and Center for Brain Science, Harvard University, Cambridge, MA 02138, USA.
Harvard University · USUniversity of Massachusetts Chan Medical School · USUniversity of Pennsylvania · US

Funding

Molecular and neuronal mechanisms of complex behaviorsR01GM084491 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI ALKEMA, MARK · 2008 to 2017
$3.0M
NIGMS NIH HHS GM084491NIGMS NIH HHS R01 GM084491
6 · The paper itself

Abstract

The development of optogenetics, a family of methods for using light to control neural activity via light-sensitive proteins, has provided a powerful new set of tools for neurobiology. These techniques have been particularly fruitful for dissecting neural circuits and behaviour in the compact and transparent roundworm Caenorhabditis elegans. Researchers have used optogenetic reagents to manipulate numerous excitable cell types in the worm, from sensory neurons, to interneurons, to motor neurons and muscles. Here, we show how optogenetics applied to this transparent roundworm has contributed to our understanding of neural circuits.

Indexed as

AnimalsBehavior, AnimalCaenorhabditis elegansCaenorhabditis elegans ProteinsNeural PathwaysNeuronsOpsinsOptogeneticsSignal TransductionCaenorhabditis elegans ProteinsOpsinsCaenorhabditis elegansneural circuitsoptogenetics

Identifiers

PMID26240427
PMCPMC4528824
OpenAlexW2180635444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.