Evidence map›Paper›PMID 26240417›Full record

ArticlePhilosophical transactions of the Royal Society of London. Series B, Biological sciences2015

Understanding the brain by controlling neural activity.

Kristine Krug, C Daniel Salzman, Scott Waddell

Abstract read
In one paragraph

Article in Philosophical transactions of the Royal Society of London. Series B, Biological sciences, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Making sense: Determining the parameter space of electrical brain stimulation.Proceedings of the National Academy of Sciences of the United States of America · 2015
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Kristine KrugDeparment of Physiology, Anatomy and Genetics, University of Oxford, Oxford, UK kristine.krug@dpag.ox.ac.uk.
C Daniel SalzmanDepartments of Neuroscience and Psychiatry, Columbia University, New York, NY, USA New York State Psychiatric Institute, New York, NY 10032, USA.
Scott WaddellCentre for Neural Circuits and Behaviour, University of Oxford, Oxford, UK.

Funding

Neurophysiology underlying neural representations of valueR01MH082017 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI Stefano Fusi, C. DANIEL SALZMAN · 2008 to 2026
$11.3M
Biotechnology and Biological Sciences Research Council BB/H016902/1NIMH NIH HHS R01 MH082017NIMH NIH HHS R01-MH082017Wellcome Trust 090309Wellcome Trust 090924Wellcome Trust 101092
6 · The paper itself

Abstract

Causal methods to interrogate brain function have been employed since the advent of modern neuroscience in the nineteenth century. Initially, randomly placed electrodes and stimulation of parts of the living brain were used to localize specific functions to these areas. Recent technical developments have rejuvenated this approach by providing more precise tools to dissect the neural circuits underlying behaviour, perception and cognition. Carefully controlled behavioural experiments have been combined with electrical devices, targeted genetically encoded tools and neurochemical approaches to manipulate information processing in the brain. The ability to control brain activity in these ways not only deepens our understanding of brain function but also provides new avenues for clinical intervention, particularly in conditions where brain processing has gone awry.

Indexed as

AnimalsBehaviorBrainBrain MappingCognitionElectric StimulationHumansbehaviourbrain stimulationneural circuitsneurophysiologyoptogeneticsperception

Identifiers

PMID26240417
PMCPMC4528814

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.