ArticleProceedings of the National Academy of Sciences of the United States of America2015
Ancient hot and cold genes and chemotherapy resistance emergence.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed.
- Long-term competition experiments reveal limited adaptive evolution in human cell lines.Scientific reports · 2026Article
- Cancer as an evolutionary reversal-time for a paradigm shift.Translational breast cancer research : a journal focusing on translational research in breast cancer · 2026Article
- Zebrafish: unraveling genetic complexity through duplicated genes.Development genes and evolution · 2024Review
- Disruption of metazoan gene regulatory networks in cancer alters the balance of co-expression between genes of unicellular and multicellular origins.Genome biology · 2024Article
- Pan-cancer surveys indicate cell cycle-related roles of primate-specific genes in tumors and embryonic cerebrum.Genome biology · 2022Article
- Origin and evolution of animal multicellularity in the light of phylogenomics and cancer genetics.Medical oncology (Northwood, London, England) · 2022Article
- Identification of a signature of evolutionarily conserved stress-induced mutagenesis in cancer.Frontiers in genetics · 2022Article
- Inferring initial state of the ancestral network of cellular fate decision: a case study of phage lambda.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2021Article
- Reverting to single-cell biology: The predictions of the atavism theory of cancer.Progress in biophysics and molecular biology · 2021Article
- Cancer progression as a sequence of atavistic reversions.BioEssays : news and reviews in molecular, cellular and developmental biology · 2021Article
- Patient-Specific Organoid and Organ-on-a-Chip: 3D Cell-Culture Meets 3D Printing and Numerical Simulation.Advanced biology · 2021Review
- Stepping From Modeling Cancer Plasticity to the Philosophy of Cancer.Frontiers in genetics · 2020Article
- The role of heterogeneous environment and docetaxel gradient in the emergence of polyploid, mesenchymal and resistant prostate cancer cells.Clinical & experimental metastasis · 2019Article
- Article
- Microfluidics in Malignant Glioma Research and Precision Medicine.Advanced biosystems · 2018Article
- How the evolution of multicellularity set the stage for cancer.British journal of cancer · 2018Review
- Cancer cells arise from bacteria.Cancer cell international · 2018Article
- Aerosol Immunotherapy with or without Cisplatin for metastatic lung cancer non-small cell lung cancer disease:Journal of Cancer · 2018Article
- Experimental evolution and proximate mechanisms in biology.Synthetic and systems biotechnology · 2017Review
- Epithelial and mesenchymal prostate cancer cell population dynamics on a complex drug landscape.Convergent science physical oncology · 2017Article
Corrections and comments
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Authors and funding
11 authors.
Funding
Abstract
We use a microfabricated ecology with a doxorubicin gradient and population fragmentation to produce a strong Darwinian selective pressure that drives forward the rapid emergence of doxorubicin resistance in multiple myeloma (MM) cancer cells. RNA sequencing of the resistant cells was used to examine (i) emergence of genes with high de novo substitution densities (i.e., hot genes) and (ii) genes never substituted (i.e., cold genes). The set of cold genes, which were 21% of the genes sequenced, were further winnowed down by examining excess expression levels. Both the most highly substituted genes and the most highly expressed never-substituted genes were biased in age toward the most ancient of genes. This would support the model that cancer represents a revision back to ancient forms of life adapted to high fitness under extreme stress, and suggests that these ancient genes may be targets for cancer therapy.
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